{Reference Type}: Case Reports
{Title}: Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy.
{Author}: Yasuoka S;Yuasa T;Fujiwara M;Fujisaki J;Inamura K;Komai Y;Numao N;Yamamoto S;Yonese J;
{Journal}: IJU Case Rep
{Volume}: 4
{Issue}: 3
{Year}: May 2021
暂无{DOI}: 10.1002/iju5.12261
{Abstract}: <B>BACKGROUND: </B>Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow-up periods are growing longer, the rate of unusual visceral metastases may increase.<BR><B>METHODS: </B>A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow-up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow-up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma.<BR><B>CONCLUSIONS: </B>We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long-term follow-up.