%0 Case Reports
%T Unusual metastasis from renal cell cancer after partial nephrectomy and sequential targeted therapy.
%A Yasuoka S
%A Yuasa T
%A Fujiwara M
%A Fujisaki J
%A Inamura K
%A Komai Y
%A Numao N
%A Yamamoto S
%A Yonese J
%J IJU Case Rep
%V 4
%N 3
%D May 2021
%M 33977239
暂无%R 10.1002/iju5.12261
%X <B>BACKGROUND: </B>Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow-up periods are growing longer, the rate of unusual visceral metastases may increase.<BR><B>METHODS: </B>A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow-up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow-up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma.<BR><B>CONCLUSIONS: </B>We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long-term follow-up.