Primary Extra-Nodal DLBCL of Glands: Our Experiences outside Guidelines of Treatment.

• 影响指数: 3.16
• 发表时间: Mar 2021 5
• 来源期刊: Healthcare (Basel)
• DOI: 10.3390/healthcare9030286
• PMID: 33807793
• 文章类型: Case Reports
• 作者列表: Sica A,Santagata M,Sagnelli C,Rambaldi P,Franco R,Creta M,Vitiello P,Caccavale S,Tammaro V,Sagnelli E,Ronchi A

关键词: non-Hodgkin lymphoma; parotid gland lymphoma; primary extra-nodal lymphoma; thyroid lymphoma

Abstract

Lymphomas usually involve lymph nodes and other lymphoid tissues, but sometimes occur in non-lymphoid organs, called extra-nodal sites. Primary diffuse extra-lymph node large B-cell lymphoma (DLBCL) of the thyroid and parotid gland have been observed rarely. According to the most accredited guidelines, primary extra-nodal DLBCL of the parotid and thyroid glands should be treated with three cycles of R-CHOP followed by radiotherapy of the involved site (ISRT). Surgery alone is not enough to treat DLBCL. We describe two unusual cases of primary extra-nodal DLBCL in elderly patients treated exclusively with surgical resection, given the inability to apply chemotherapy. Both patients achieved clinical recovery, which was maintained after a follow-up of more than 18 months, despite not having performed the indicated chemotherapy protocol. The two cases presented here, and a few others reported in the literature, should be considered exceptions to the rule, and do not allow the conclusion that surgery alone might be sufficient for complete remission.