{Reference Type}: Case Reports
{Title}: Primary Extra-Nodal DLBCL of Glands: Our Experiences outside Guidelines of Treatment.
{Author}: Sica A;Santagata M;Sagnelli C;Rambaldi P;Franco R;Creta M;Vitiello P;Caccavale S;Tammaro V;Sagnelli E;Ronchi A;
{Journal}: Healthcare (Basel)
{Volume}: 9
{Issue}: 3
{Year}: Mar 2021 5
{Factor}: 3.16
{DOI}: 10.3390/healthcare9030286
{Abstract}: Lymphomas usually involve lymph nodes and other lymphoid tissues, but sometimes occur in non-lymphoid organs, called extra-nodal sites. Primary diffuse extra-lymph node large B-cell lymphoma (DLBCL) of the thyroid and parotid gland have been observed rarely. According to the most accredited guidelines, primary extra-nodal DLBCL of the parotid and thyroid glands should be treated with three cycles of R-CHOP followed by radiotherapy of the involved site (ISRT). Surgery alone is not enough to treat DLBCL. We describe two unusual cases of primary extra-nodal DLBCL in elderly patients treated exclusively with surgical resection, given the inability to apply chemotherapy. Both patients achieved clinical recovery, which was maintained after a follow-up of more than 18 months, despite not having performed the indicated chemotherapy protocol. The two cases presented here, and a few others reported in the literature, should be considered exceptions to the rule, and do not allow the conclusion that surgery alone might be sufficient for complete remission.