Abstract：
OBJECTIVE: Modern intensity-modulated radiotherapy (IMRT) is frequently applied to treat patients with nasal cavity and paranasal sinus (NC/PNS) malignancies.
METHODS: One hundred and four patients who underwent radiotherapy (RT) between 1994 and 2020 were recognized. This analysis compared conventional-radiotherapy (CRT) and image-guided IMRT outcomes for NC/PNS malignancies.
RESULTS: The median follow-up was 69 months. Eighty-eight patients (85%) were managed with image-guided IMRT. The median initial radiation dose was 65 Gy, with 68 Gy applied for patients treated with primary RT versus 63 Gy applied for adjuvant therapy (p=0.1). The 5-year locoregional control (LRC) was 85%. The locoregional recurrence rate was 18% following IMRT versus 31% in the 2D/3D-conventional RT group (p=0.09). Moreover, IMRT was associated with a lower inner-ear toxicity rate (8% vs. 20%, respectively; p=0.045).
CONCLUSIONS: IMRT appears to be linked with higher LRC and lower inner-ear acute toxicities compared to conventional RT.
METHODS: One hundred and four patients who underwent radiotherapy (RT) between 1994 and 2020 were recognized. This analysis compared conventional-radiotherapy (CRT) and image-guided IMRT outcomes for NC/PNS malignancies.
RESULTS: The median follow-up was 69 months. Eighty-eight patients (85%) were managed with image-guided IMRT. The median initial radiation dose was 65 Gy, with 68 Gy applied for patients treated with primary RT versus 63 Gy applied for adjuvant therapy (p=0.1). The 5-year locoregional control (LRC) was 85%. The locoregional recurrence rate was 18% following IMRT versus 31% in the 2D/3D-conventional RT group (p=0.09). Moreover, IMRT was associated with a lower inner-ear toxicity rate (8% vs. 20%, respectively; p=0.045).
CONCLUSIONS: IMRT appears to be linked with higher LRC and lower inner-ear acute toxicities compared to conventional RT.
摘要：
目的：现代调强放疗（IMRT）常用于治疗鼻腔和鼻旁窦（NC/PNS）恶性肿瘤。
方法：确认了1994年至2020年间接受放疗（RT）的104例患者。该分析比较了常规放疗（CRT）和图像引导IMRT对NC/PNS恶性肿瘤的结果。
结果：中位随访时间为69个月。88例患者（85％）接受了图像引导的IMRT治疗。中位初始辐射剂量为65Gy，68Gy用于接受主要RT治疗的患者，而63Gy用于辅助治疗（p=0.1）。5年局部区域控制（LRC）为85％。IMRT后局部区域复发率为18％，而2D/3D常规RT组为31％（p=0.09）。此外，IMRT与较低的内耳毒性率相关(8%vs.20%,分别为；p=0.045)。
结论：与常规RT相比，IMRT似乎与更高的LRC和更低的内耳急性毒性相关。
方法：确认了1994年至2020年间接受放疗（RT）的104例患者。该分析比较了常规放疗（CRT）和图像引导IMRT对NC/PNS恶性肿瘤的结果。
结果：中位随访时间为69个月。88例患者（85％）接受了图像引导的IMRT治疗。中位初始辐射剂量为65Gy，68Gy用于接受主要RT治疗的患者，而63Gy用于辅助治疗（p=0.1）。5年局部区域控制（LRC）为85％。IMRT后局部区域复发率为18％，而2D/3D常规RT组为31％（p=0.09）。此外，IMRT与较低的内耳毒性率相关(8%vs.20%,分别为；p=0.045)。
结论：与常规RT相比，IMRT似乎与更高的LRC和更低的内耳急性毒性相关。
