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Abstract：
Filamin A(FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration. It is involved in signal transduction, cell proliferation and differentiation, pseudopodia formation, vesicle transport, tumor resistance and genetic diseases by binding with interacting proteins. In order to fully elucidate the structure, function and pathogenesis of FLNa, we summarized all substances which directly or indirectly act on FLNa so far, upstream and downstream targets which having effect on it, signaling pathways and their functions. It also recorded the expression and effect of FLNa in different diseases, including hereditary disease and tumors.
摘要：
FilaminA（FLNa）是一种肌动蛋白结合蛋白，参与细胞骨架的形成，在细胞骨架中锚定多种蛋白质，调节细胞粘附和迁移。它参与信号转导，细胞增殖和分化，伪足形成,囊泡运输，与相互作用蛋白结合的肿瘤抗性和遗传疾病。为了充分阐明结构，FLNa的功能和发病机制，我们总结了迄今为止所有直接或间接作用于FLNa的物质，对其有影响的上游和下游目标，信号通路及其功能。同时记录了FLNa在不同疾病中的表达和作用,包括遗传性疾病和肿瘤.
