PDF(Sci-hub)
Abstract：
UNASSIGNED: Kidneys obtained from deceased donors increase the incidence of delayed graft function (DGF) after renal transplantation. Here we investigated the influence of the risk factors of donors with DGF, and developed a donor risk scoring system for DGF prediction.
UNASSIGNED: This retrospective study was conducted in 1807 deceased kidney donors and 3599 recipients who received donor kidneys via transplants in 29 centers in China. We quantified DGF associations with donor clinical characteristics. A donor risk scoring system was developed and validated using an independent sample set.
UNASSIGNED: The incidence of DGF from donors was 19.0%. Six of the donor characteristics analyzed, i.e., age, cause of death, history of hypertension, terminal serum creatinine, persistence of hypotension, and cardiopulmonary resuscitation (CPR) time were risk factors for DGF. A 49-point scoring system of donor risk was established for DGF prediction and exhibited a superior degree of discrimination. External validation of DGF prediction revealed area under the receiver-operating characteristic (AUC) curves of 0.7552.
UNASSIGNED: Our study determined the deceased donor risk factors related to DGF after renal transplantation pertinent to the Chinese cohort. The scoring system developed here had superior diagnostic significance and consistency and can be used by clinicians to make evidence-based decisions on the quality of kidneys from deceased donors and guide renal transplantation therapy.
UNASSIGNED: This retrospective study was conducted in 1807 deceased kidney donors and 3599 recipients who received donor kidneys via transplants in 29 centers in China. We quantified DGF associations with donor clinical characteristics. A donor risk scoring system was developed and validated using an independent sample set.
UNASSIGNED: The incidence of DGF from donors was 19.0%. Six of the donor characteristics analyzed, i.e., age, cause of death, history of hypertension, terminal serum creatinine, persistence of hypotension, and cardiopulmonary resuscitation (CPR) time were risk factors for DGF. A 49-point scoring system of donor risk was established for DGF prediction and exhibited a superior degree of discrimination. External validation of DGF prediction revealed area under the receiver-operating characteristic (AUC) curves of 0.7552.
UNASSIGNED: Our study determined the deceased donor risk factors related to DGF after renal transplantation pertinent to the Chinese cohort. The scoring system developed here had superior diagnostic significance and consistency and can be used by clinicians to make evidence-based decisions on the quality of kidneys from deceased donors and guide renal transplantation therapy.
摘要：
■从已故供体获得的肾脏增加了肾移植后延迟移植功能（DGF）的发生率。在这里，我们调查了DGF供体的危险因素的影响，并开发了用于DGF预测的供体风险评分系统。
这项回顾性研究是在中国29个中心的1807名已故肾脏供体和3599名通过移植接受供体肾脏的受体中进行的。我们量化了DGF与供体临床特征的关联。使用独立的样本集开发并验证了供体风险评分系统。
■来自供体的DGF的发生率为19.0%。分析了六个供体特征，即，年龄,死因,高血压病史,终末血清肌酐，持续低血压，心肺复苏（CPR）时间是DGF的危险因素。建立了用于DGF预测的49分供体风险评分系统，并表现出优异的区分度。DGF预测的外部验证显示受试者工作特征（AUC）曲线下的面积为0.7552。
■我们的研究确定了与中国队列相关的肾移植后DGF相关的死亡供者危险因素。此处开发的评分系统具有出色的诊断意义和一致性，可由临床医生用于对已故供体的肾脏质量做出基于证据的决定并指导肾移植治疗。
这项回顾性研究是在中国29个中心的1807名已故肾脏供体和3599名通过移植接受供体肾脏的受体中进行的。我们量化了DGF与供体临床特征的关联。使用独立的样本集开发并验证了供体风险评分系统。
■来自供体的DGF的发生率为19.0%。分析了六个供体特征，即，年龄,死因,高血压病史,终末血清肌酐，持续低血压，心肺复苏（CPR）时间是DGF的危险因素。建立了用于DGF预测的49分供体风险评分系统，并表现出优异的区分度。DGF预测的外部验证显示受试者工作特征（AUC）曲线下的面积为0.7552。
■我们的研究确定了与中国队列相关的肾移植后DGF相关的死亡供者危险因素。此处开发的评分系统具有出色的诊断意义和一致性，可由临床医生用于对已故供体的肾脏质量做出基于证据的决定并指导肾移植治疗。
