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Abstract：
We examined parental diabetes monitoring behaviors in a cohort of children at increased genetic risk for type 1 diabetes. We hypothesized that being informed of a positive islet autoantibody (IA) would increase monitoring behaviors.
The Environmental Determinants of Diabetes in the Young (TEDDY) study follows 8676 children with high-risk human leucocyte antigen-DQ genotypes from birth to age 15, including general population (GP) children and those with a first-degree relative (FDR) with diabetes. Data on parental monitoring behaviors were solicited yearly. Serum samples were tested for IA and parents were informed of child results. We examined parental monitoring behaviors during the first 7 years of TEDDY.
In IA- children, the most common monitoring behavior was participating in TEDDY study tasks; up to 49.8% and 44.2% of mothers and fathers, respectively, reported this. Among FDRs, 7%-10% reported watching for diabetes symptoms and 7%-9% reported monitoring the child\'s glucose, for mothers and fathers, respectively. After IA+ notification, all monitoring behaviors significantly increased in GP parents; only glucose monitoring increased in FDR parents and these behaviors continued for up to 4 years. FDR status, accurate diabetes risk perception, and anxiety were associated with glucose monitoring in IA+ and IA- cohorts.
Many parents view TEDDY participation as a way to monitor for type 1 diabetes, a benefit of enrollment in a longitudinal study with no prevention offered. IA+ notification increases short- and long-term monitoring behaviors. For IA- and IA+ children, FDR parents engage in glucose monitoring, even when not instructed to do so.
The Environmental Determinants of Diabetes in the Young (TEDDY) study follows 8676 children with high-risk human leucocyte antigen-DQ genotypes from birth to age 15, including general population (GP) children and those with a first-degree relative (FDR) with diabetes. Data on parental monitoring behaviors were solicited yearly. Serum samples were tested for IA and parents were informed of child results. We examined parental monitoring behaviors during the first 7 years of TEDDY.
In IA- children, the most common monitoring behavior was participating in TEDDY study tasks; up to 49.8% and 44.2% of mothers and fathers, respectively, reported this. Among FDRs, 7%-10% reported watching for diabetes symptoms and 7%-9% reported monitoring the child\'s glucose, for mothers and fathers, respectively. After IA+ notification, all monitoring behaviors significantly increased in GP parents; only glucose monitoring increased in FDR parents and these behaviors continued for up to 4 years. FDR status, accurate diabetes risk perception, and anxiety were associated with glucose monitoring in IA+ and IA- cohorts.
Many parents view TEDDY participation as a way to monitor for type 1 diabetes, a benefit of enrollment in a longitudinal study with no prevention offered. IA+ notification increases short- and long-term monitoring behaviors. For IA- and IA+ children, FDR parents engage in glucose monitoring, even when not instructed to do so.
摘要：
我们在1型糖尿病遗传风险增加的儿童队列中检查了父母的糖尿病监测行为。我们假设被告知阳性胰岛自身抗体（IA）会增加监测行为。
青年糖尿病的环境决定因素（TEDDY）研究跟踪8676名从出生到15岁的高风险人类白细胞抗原DQ基因型儿童，包括普通人群（GP）儿童和一级亲属（FDR）患有糖尿病的儿童。每年征集有关父母监护行为的数据。对血清样品进行IA测试，并告知父母儿童结果。我们检查了TEDDY前7年的父母监护行为。
在IA-儿童中，最常见的监测行为是参与TEDDY研究任务；高达49.8%和44.2%的父母，分别,报道这个。在FDR中，7%-10%报告观察糖尿病症状，7%-9%报告监测儿童的血糖，对于父母来说，分别。IA+通知后，GP父母的所有监测行为均显著增加;只有FDR父母的血糖监测增加,这些行为持续长达4年.FDR状态,准确的糖尿病风险感知，在IA+和IA-队列中,焦虑与血糖监测相关.
许多家长将TEDDY参与视为监测1型糖尿病的一种方式。纳入一项没有提供预防措施的纵向研究的好处。IA+通知增加了短期和长期监测行为。对于IA-和IA+儿童，FDR父母从事血糖监测，即使没有指示这样做。
青年糖尿病的环境决定因素（TEDDY）研究跟踪8676名从出生到15岁的高风险人类白细胞抗原DQ基因型儿童，包括普通人群（GP）儿童和一级亲属（FDR）患有糖尿病的儿童。每年征集有关父母监护行为的数据。对血清样品进行IA测试，并告知父母儿童结果。我们检查了TEDDY前7年的父母监护行为。
在IA-儿童中，最常见的监测行为是参与TEDDY研究任务；高达49.8%和44.2%的父母，分别,报道这个。在FDR中，7%-10%报告观察糖尿病症状，7%-9%报告监测儿童的血糖，对于父母来说，分别。IA+通知后，GP父母的所有监测行为均显著增加;只有FDR父母的血糖监测增加,这些行为持续长达4年.FDR状态,准确的糖尿病风险感知，在IA+和IA-队列中,焦虑与血糖监测相关.
许多家长将TEDDY参与视为监测1型糖尿病的一种方式。纳入一项没有提供预防措施的纵向研究的好处。IA+通知增加了短期和长期监测行为。对于IA-和IA+儿童，FDR父母从事血糖监测，即使没有指示这样做。
