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Abstract：
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as \"an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed around small blood vessels at the depths of cortical sulci and in an irregular pattern,\" based on review of 25 tauopathy cases. In 2016, the consensus panel met again to review and refine the preliminary criteria, with consideration around the minimum threshold for diagnosis and the reproducibility of a proposed pathological staging scheme. Eight neuropathologists evaluated 27 cases of tauopathies (17 CTE cases), blinded to clinical and demographic information. Generalized estimating equation analyses showed a statistically significant association between the raters and CTE diagnosis for both the blinded (OR = 72.11, 95% CI = 19.5-267.0) and unblinded rounds (OR = 256.91, 95% CI = 63.6-1558.6). Based on the challenges in assigning CTE stage, the panel proposed a working protocol including a minimum threshold for CTE diagnosis and an algorithm for the assessment of CTE severity as \"Low CTE\" or \"High CTE\" for use in future clinical, pathological, and molecular studies.
摘要：
慢性创伤性脑病（CTE）是一种与头部创伤相关的神经退行性疾病。2015年，由NINDS/NIBIB资助的神经病理学家小组定义了CTE的初步共识神经病理学标准，包括CTE的病理损害，即“在皮质沟深处的小血管周围分布的神经元和星形胶质细胞中异常高磷酸化tau（p-tau）的积累，“基于对25例tau蛋白病病例的回顾。2016年，共识小组再次开会，审查和完善初步标准，考虑到诊断的最低阈值和拟议的病理分期方案的可重复性。八名神经病理学家评估了27例tau蛋白病变（17例CTE），对临床和人口统计信息视而不见。广义估计方程分析显示，对于盲法（OR=72.11，95％CI=19.5-267.0）和非盲法（OR=256.91，95％CI=63.6-1558.6），评估者与CTE诊断之间存在统计学上的显着关联。基于CTE阶段分配的挑战，该小组提出了一项工作方案，包括CTE诊断的最低阈值和CTE严重程度评估算法，如“低CTE”或“高CTE”，供未来临床使用。病态,和分子研究。
