Abstract：
This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
摘要：
本文使用国际癌症研究机构提供的GLOBOCAN2020癌症发病率和死亡率估计值提供了全球癌症负担的最新信息。全球,2020年估计有1930万新癌症病例(1810万不含非黑色素瘤皮肤癌)和近10.0万例癌症死亡(990万不含非黑色素瘤皮肤癌).女性乳腺癌已超过肺癌，成为最常见的诊断癌症，估计有230万新病例(11.7%)，其次是肺（11.4%），结直肠(10.0%)，前列腺(7.3%)，胃癌（5.6%）。肺癌仍然是癌症死亡的主要原因，估计有180万人死亡(18%)，其次是结直肠(9.4%)，肝脏（8.3%），胃（7.7％），和女性乳腺癌(6.9%)。与过渡国家相比，男女两性的总体发病率从2倍提高到3倍。而男性死亡率差异<2倍，女性差异不大。女性乳腺癌和宫颈癌的死亡率，然而,与转型国家相比，转型国家的比例要高得多(分别为15.0比12.8/100,000和12.4比5.2/100,000)。预计2040年全球癌症负担将为2840万例，比2020年增长47%，由于人口变化，转型国家(64%至95%)与转型国家(32%至56%)相比有更大的增长。尽管与全球化和经济增长相关的风险因素增加可能会进一步加剧这种情况。努力建立可持续的基础设施，以在转型国家传播癌症预防措施和提供癌症护理，对于全球癌症控制至关重要。
