缺乏 T - bet 的 Th2 细胞通过 IL - 10 抑制幼稚和记忆 T 细胞应答。
关键词: CD8+ T cells IL-10 T-bet autoimmunity memory responses
Mesh : Animals CD8-Positive T-Lymphocytes / immunology Dendritic Cells / immunology Diabetes Mellitus, Type 1 / immunology prevention & control Down-Regulation Epitopes / immunology Immunologic Memory Interleukin-10 / metabolism Lymphocyte Activation / immunology Lymphocytic Choriomeningitis / immunology virology Lymphocytic choriomeningitis virus / immunology Mice, Inbred C57BL Mice, Knockout T-Box Domain Proteins / deficiency metabolism Th2 Cells / immunology Mice
来 源:
DOI:10.1073/pnas.2002787118
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