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Abstract：
There is an ongoing debate on whether fructose plays a role in the development of nonalcoholic fatty liver disease.
The aim of this study was to investigate the effects of fructose restriction on intrahepatic lipid (IHL) content in a double-blind randomized controlled trial using an isocaloric comparator.
Between March 2017 and October 2019, 44 adult overweight individuals with a fatty liver index ≥ 60 consumed a 6-wk fructose-restricted diet (<7.5 g/meal and <10 g/d) and were randomly assigned to supplementation with sachets of glucose (= intervention group) or fructose (= control group) 3 times daily. Participants and assessors were blinded to the allocation. IHL content, assessed by proton magnetic resonance spectroscopy, was the primary outcome and glucose tolerance and serum lipids were the secondary outcomes. All measurements were conducted in Maastricht University Medical Center.
Thirty-seven participants completed the study protocol. After 6 wk of fructose restriction, dietary fructose intake and urinary fructose excretion were significantly lower in the intervention group (difference: -57.0 g/d; 95% CI: -77.9, -39.5 g/d; and -38.8 μmol/d; 95% CI: -91.2, -10.7 μmol/d, respectively). Although IHL content decreased in both the intervention and control groups (P < 0.001 and P = 0.003, respectively), the change in IHL content was more pronounced in the intervention group (difference: -0.7% point, 95% CI: -2.0, -0.03% point). The changes in glucose tolerance and serum lipids were not significantly different between groups.
Six weeks of fructose restriction per se led to a small, but statistically significant, decrease in IHL content in comparison with an isocaloric control group.This trial was registered at clinicaltrials.gov as NCT03067428.
The aim of this study was to investigate the effects of fructose restriction on intrahepatic lipid (IHL) content in a double-blind randomized controlled trial using an isocaloric comparator.
Between March 2017 and October 2019, 44 adult overweight individuals with a fatty liver index ≥ 60 consumed a 6-wk fructose-restricted diet (<7.5 g/meal and <10 g/d) and were randomly assigned to supplementation with sachets of glucose (= intervention group) or fructose (= control group) 3 times daily. Participants and assessors were blinded to the allocation. IHL content, assessed by proton magnetic resonance spectroscopy, was the primary outcome and glucose tolerance and serum lipids were the secondary outcomes. All measurements were conducted in Maastricht University Medical Center.
Thirty-seven participants completed the study protocol. After 6 wk of fructose restriction, dietary fructose intake and urinary fructose excretion were significantly lower in the intervention group (difference: -57.0 g/d; 95% CI: -77.9, -39.5 g/d; and -38.8 μmol/d; 95% CI: -91.2, -10.7 μmol/d, respectively). Although IHL content decreased in both the intervention and control groups (P < 0.001 and P = 0.003, respectively), the change in IHL content was more pronounced in the intervention group (difference: -0.7% point, 95% CI: -2.0, -0.03% point). The changes in glucose tolerance and serum lipids were not significantly different between groups.
Six weeks of fructose restriction per se led to a small, but statistically significant, decrease in IHL content in comparison with an isocaloric control group.This trial was registered at clinicaltrials.gov as NCT03067428.
摘要：
关于果糖是否在非酒精性脂肪性肝病的发展中起作用的争论正在进行。
这项研究的目的是在使用等热量比较器的双盲随机对照试验中研究果糖限制对肝内脂质（IHL）含量的影响。
在2017年3月至2019年10月之间，44名脂肪肝指数≥60的成年超重个体食用6周果糖限制饮食（<7.5g/餐和<10g/d），并被随机分配每天3次补充小袋葡萄糖（=干预组）或果糖（=对照组）。参与者和评估者对分配视而不见。IHL内容，通过质子磁共振波谱评估，主要结局为糖耐量和血脂,次要结局为糖耐量.所有测量均在马斯特里赫特大学医学中心进行。
37名参与者完成了研究方案。限制果糖6周后，干预组的膳食果糖摄入量和尿果糖排泄量显着降低（差异：-57.0g/d；95％CI：-77.9，-39.5g/d；和-38.8μmol/d；95％CI：-91.2，-10.7μmol/d，分别)。尽管干预组和对照组的IHL含量均下降（分别为P<0.001和P=0.003），IHL含量的变化在干预组中更为明显(差异：-0.7%，95%CI：-2.0，-0.03%点）。各组之间糖耐量和血脂的变化没有显着差异。
六周的果糖限制本身导致了一个小的，但具有统计学意义，与等热量对照组相比，IHL含量降低。该试验在clinicaltrials.gov注册为NCT03067428。
这项研究的目的是在使用等热量比较器的双盲随机对照试验中研究果糖限制对肝内脂质（IHL）含量的影响。
在2017年3月至2019年10月之间，44名脂肪肝指数≥60的成年超重个体食用6周果糖限制饮食（<7.5g/餐和<10g/d），并被随机分配每天3次补充小袋葡萄糖（=干预组）或果糖（=对照组）。
37名参与者完成了研究方案。
六周的果糖限制本身导致了一个小的，
