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Abstract：
Toxoplasma gondii and Eimeria spp. are widely prevalent Coccidian parasites that undergo sexual reproduction during their life cycle. T. gondii can infect any warm-blooded animal in its asexual cycle; however, its sexual cycle is restricted to felines. Eimeria spp. are usually restricted to one host species, and their whole life cycle is completed within this same host. The literature reviewed in this article comprises the recent findings regarding the unique biology of the sexual development of T. gondii and Eimeria spp. The molecular basis of sex in these pathogens has been significantly unraveled by new findings in parasite differentiation along with transcriptional analysis of T. gondii and Eimeria spp. pre-sexual and sexual stages. Focusing on the metabolic networks, analysis of these transcriptome datasets shows enrichment for several different metabolic pathways. Transcripts for glycolysis enzymes are consistently more abundant in T. gondii cat infection stages than the asexual tachyzoite stage and Eimeria spp. merozoite and gamete stages compared to sporozoites. Recent breakthroughs in host-pathogen interaction and host restriction have significantly expanded the understating of the unique biology of these pathogens. This review aims to critically explore advances in the sexual cycle of Coccidia parasites with the ultimate goal of comparing and analyzing the sexual cycle of Eimeria spp. and T. gondii.
摘要：
弓形虫和艾美球虫。是广泛流行的球虫寄生虫，在其生命周期中经历有性生殖。弓形虫可以在无性周期中感染任何温血动物；然而，它的性周期仅限于猫科动物。艾美球虫。通常仅限于一个宿主物种，它们的整个生命周期都在同一个宿主中完成。本文综述的文献包括有关弓形虫和艾美球虫性发育的独特生物学的最新发现。寄生虫分化的新发现以及弓形虫和艾美球虫的转录分析已大大揭示了这些病原体中性别的分子基础。性前期和性阶段。专注于代谢网络，对这些转录组数据集的分析显示了几种不同代谢途径的富集。在弓形虫猫感染阶段，糖酵解酶的转录本始终比无性速殖子和艾美球虫更丰富。与子孢子相比，裂殖子孢子和配子阶段。最近在宿主-病原体相互作用和宿主限制方面的突破显着扩大了对这些病原体独特生物学的低估。这篇综述旨在批判性地探讨球虫寄生虫性周期的进展，最终目的是比较和分析艾美球虫的性周期。还有T.Gondii.
