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Abstract：
OBJECTIVE: To evaluate the effectiveness of different diagnostic variables measured on panoramic radiographs (PAN) to predict spontaneous eruption of palatally displaced canine (PDC) after interceptive extraction in late mixed dentition.
METHODS: Digital databases (MEDLINE, CENTRAL (Cochrane), Scopus, clinicaltrials.gov, ISRCTN registry) and hand searches were performed up to March 2020. Both randomized and non-randomized controlled trials were considered for the review. Study selection, data extraction, risk of bias assessment (RoB2.0 and ROBINS-I), and the certainty of evidence evaluation (GRADE) were performed according to Cochrane Handbook for Systematic Reviews of Interventions. The random-effects method for quantitative synthesis of dichotomous as well as continuous data was used.
RESULTS: Out of 767 retrieved records, 4 controlled trials fulfilled the eligibility criteria and were included in the review. Studies were assessed at low risk of bias except one. Overall certainty was strong to moderate. PDCs in distal sectors (RR: 1.621; 95%CI: 1.259 to 2.086; P<0.001) and alpha-angle <30° (SMD: -1.350; 95%CI: 1.924 to -0.776; P<0.001) were significantly benefited from interceptive extraction. However, Vertical distance of PDC cusp tip from occlusal plane had statistically insignificant (p: 0.855) roll on eruption prediction.
CONCLUSIONS: Interceptive extraction at a younger age, initial horizontal localization (sector position), and alpha-angle (initial mesial inclination) are the most important variables predicting the spontaneous eruption of palatally displaced canines. Findings of this review can be utilized to make evidence-based decisions for managing PDCs with diverse sectors and mesial inclinations. However, well-designed clinical trials are recommended to strengthen the evidence.
METHODS: Digital databases (MEDLINE, CENTRAL (Cochrane), Scopus, clinicaltrials.gov, ISRCTN registry) and hand searches were performed up to March 2020. Both randomized and non-randomized controlled trials were considered for the review. Study selection, data extraction, risk of bias assessment (RoB2.0 and ROBINS-I), and the certainty of evidence evaluation (GRADE) were performed according to Cochrane Handbook for Systematic Reviews of Interventions. The random-effects method for quantitative synthesis of dichotomous as well as continuous data was used.
RESULTS: Out of 767 retrieved records, 4 controlled trials fulfilled the eligibility criteria and were included in the review. Studies were assessed at low risk of bias except one. Overall certainty was strong to moderate. PDCs in distal sectors (RR: 1.621; 95%CI: 1.259 to 2.086; P<0.001) and alpha-angle <30° (SMD: -1.350; 95%CI: 1.924 to -0.776; P<0.001) were significantly benefited from interceptive extraction. However, Vertical distance of PDC cusp tip from occlusal plane had statistically insignificant (p: 0.855) roll on eruption prediction.
CONCLUSIONS: Interceptive extraction at a younger age, initial horizontal localization (sector position), and alpha-angle (initial mesial inclination) are the most important variables predicting the spontaneous eruption of palatally displaced canines. Findings of this review can be utilized to make evidence-based decisions for managing PDCs with diverse sectors and mesial inclinations. However, well-designed clinical trials are recommended to strengthen the evidence.
摘要：
目的：评估在全景X线照片（PAN）上测量的不同诊断变量对预测晚期混合牙列拦截拔除后pat位移位犬（PDC）自发爆发的有效性。
方法：数字数据库(MEDLINE，CENTRAL(Cochrane),Scopus,clinicaltrials.gov,ISRCTN注册表）和手工搜索已进行到2020年3月。该综述考虑了随机和非随机对照试验。研究选择，数据提取,偏见风险评估(RoB2.0和ROBINS-I)，根据《Cochrane干预措施系统评价手册》进行证据确定性评价(GRADE)。使用随机效应方法定量合成二分和连续数据。
结果：在767条检索记录中，4项对照试验符合资格标准，并纳入审查。除一项外，研究的偏倚风险较低。总体确定性强至中等。远端部门的PDCs（RR：1.621；95CI：1.259至2.086；P<0.001）和α角<30°（SMD：-1.350；95CI：1.924至-0.776；P<0.001）显著受益于拦截提取。然而,PDC尖尖与咬合平面的垂直距离对喷发预测具有统计学意义（p：0.855）。
结论：在较年轻的年龄，初始水平定位（扇区位置），和α角（初始近中倾角）是预测pal位犬科动物自发爆发的最重要变量。这项审查的结果可用于做出基于证据的决策，以管理具有不同部门和中等倾向的PDC。然而,建议精心设计的临床试验来加强证据。
方法：数字数据库(MEDLINE，CENTRAL(Cochrane),Scopus,clinicaltrials.gov,ISRCTN注册表）和手工搜索已进行到2020年3月。该综述考虑了随机和非随机对照试验。研究选择，数据提取,偏见风险评估(RoB2.0和ROBINS-I)，根据《Cochrane干预措施系统评价手册》进行证据确定性评价(GRADE)。使用随机效应方法定量合成二分和连续数据。
结果：在767条检索记录中，4项对照试验符合资格标准，并纳入审查。除一项外，研究的偏倚风险较低。总体确定性强至中等。远端部门的PDCs（RR：1.621；95CI：1.259至2.086；P<0.001）和α角<30°（SMD：-1.350；95CI：1.924至-0.776；P<0.001）显著受益于拦截提取。然而,PDC尖尖与咬合平面的垂直距离对喷发预测具有统计学意义（p：0.855）。
结论：在较年轻的年龄，初始水平定位（扇区位置），和α角（初始近中倾角）是预测pal位犬科动物自发爆发的最重要变量。这项审查的结果可用于做出基于证据的决策，以管理具有不同部门和中等倾向的PDC。然而,建议精心设计的临床试验来加强证据。
