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Abstract：
Fungi are a rich source of secondary metabolites with several pharmacological activities such as antifungal, antioxidant, antibacterial and anticancer to name a few. Due to the large number of diverse structured chemical compounds they produce, fungi from the phyla Ascomycota, Basidiomycota and Muccoromycota have been intensively studied for isolation of bioactive compounds. Basidiomycetes-derived secondary metabolites are known as a promising source of antibacterial compounds with activity against Gram-positive bacteria. The continued emergence of antimicrobial resistance (AMR) poses a major challenge to patient health as it leads to higher morbidity and mortality, higher hospital-stay duration and substantial economic burden in global healthcare sector. One of the key culprits for AMR crisis is Staphylococcus aureus causing community-acquired infections as the pathogen develops resistance towards multiple antibiotics. The recent emergence of community strains of S. aureus harbouring methicillin-resistant (MRSA), vancomycin-intermediate (VISA) and vancomycin-resistant (VRSA) genes associated with increased virulence is challenging. Despite the few significant developments in antibiotic research, successful MRSA therapeutic options are still needed to reduce the use of scanty and expensive second-line treatments. This paper provides an overview of findings from various studies on antibacterial secondary metabolites from basidiomycetes, with a special focus on antistaphylococcal activity.
摘要：
真菌是次级代谢产物的丰富来源，具有多种药理活性，如抗真菌，抗氧化剂，抗菌和抗癌仅举几例。由于它们产生了大量不同结构的化合物，来自子囊门的真菌，担子菌和粘菌已被深入研究以分离生物活性化合物。担子菌衍生的次级代谢产物被认为是具有抗革兰氏阳性细菌活性的抗菌化合物的有希望的来源。抗菌素耐药性（AMR）的持续出现对患者健康构成了重大挑战，因为它导致更高的发病率和死亡率。更高的住院时间和全球医疗保健部门的巨大经济负担。AMR危机的关键罪魁祸首之一是金黄色葡萄球菌引起社区获得性感染，因为病原体对多种抗生素产生耐药性。最近出现了耐甲氧西林金黄色葡萄球菌（MRSA）的社区菌株，与毒力增加相关的万古霉素中间体（VISA）和万古霉素抗性（VRSA）基因具有挑战性。尽管抗生素研究取得了一些重大进展，仍然需要成功的MRSA治疗选择,以减少使用少量和昂贵的二线治疗.本文概述了担子菌的抗菌次级代谢产物的各种研究结果，特别关注抗葡萄球菌活性。
