Mesh : Aging / genetics Animals Cellular Senescence / genetics DNA Breaks, Double-Stranded DNA Repair Female Gene Expression Regulation / genetics Genetic Predisposition to Disease Hematopoiesis / genetics Hematopoiesis, Extramedullary Hematopoietic System / physiology Histone Code / genetics Histone Demethylases / deficiency genetics physiology Immune Reconstitution Jumonji Domain-Containing Histone Demethylases / metabolism Leukemia, Experimental / genetics virology Male Mice Mice, Knockout Moloney murine leukemia virus / physiology Myeloid Cells / pathology Radiation Chimera Reactive Oxygen Species / metabolism Recombinant Proteins / metabolism Transcription Factors / metabolism Virus Integration
来 源:
DOI:10.1182/blood.2019001044
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