Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy.

• 影响指数: 15.304
• 发表时间: 01 2021
• 来源期刊: Biomaterials
• DOI: 10.1016/j.biomaterials.2020.120454
• PMID: 33160122
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 生物
• 作者列表: Gao X,Jiang S,Li C,Chen Y,Zhang Y,Huang P,Lin J

关键词: Cell membrane vesicle; Croconium dye; Near-infrared fluorescence/photoacoustic duplex imaging; Photothermal therapy; Tumor acidic microenvironment

Mesh: Cell Line, Tumor; Cell Membrane; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced; Nanoparticles; Neoplasms / therapy; Photoacoustic Techniques; Phototherapy; Photothermal Therapy; Theranostic Nanomedicine; Tumor Microenvironment

Abstract

The development of tumor acidic microenvironment-responsive theranostic agents is a research hotspot. Herein, we developed highly photostable amphiphilic croconium dye-anchored red blood cell membrane vesicle (denoted as LET-5) for tumor pH-responsive near-infrared fluorescence (NIRF) and photoacoustic (PA) duplex imaging-guided photothermal therapy. In tumor acidic microenvironment, both NIRF and PA signals of LET-5 were significantly enhanced and the photothermal effect of LET-5 was activated. Notably, cell membrane-based vesicle with enhanced stability and long blood circulation significantly improved the tumor accumulation of croconium dye, thus achieving better therapeutic effect than free croconium dye. These findings provide a promising approach to construct amphiphilic dye-anchored cell membrane vesicle for cancer theranostics.