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Abstract：
Asymptomatic SARS-CoV-2-infected individuals are thought to play major roles in virus transmission. This study aimed to analyze the characteristics of asymptomatic carriers with COVID-19 to control the spread of the virus. We retrospectively investigated the clinical characteristics of 648 consecutive subjects who were enrolled in the study and were divided into asymptomatic carriers, mild cases, ordinary cases, severe or critical cases, and evaluated their impact on disease severity by means of Spearman correlation and multiple regression analyses. Receiver operating characteristic curve analysis was conducted to determine the optimum cutoff levels of laboratory findings for diagnostic predictors of asymptomatic carriers of COVID-19. In our study, a total of 648 subjects on admission with a mean age of 45.61 y including 345 males and 303 females were enrolled in our study. The leukocyte, lymphocyte, eosinophil, platelet, C-reactive protein, interleukin-6, CD3+, CD4+, and CD8 + T lymphocyte levels, and the erythrocyte sedimentation rate differed significantly among the groups (all p ≤ 0.05). Disease severity was negatively associated with the CD3+ (r = -0.340; p < 0.001), CD4+ (r = -0.290; p = 0.001) and CD8+ (r = -0.322; p < 0.001) T lymphocyte levels. The significant diagnostic predictors of asymptomatic carriers of COVID-19 included the blood cell, cytokine, and T lymphocyte subset levels. Inflammation and immune response may play important roles in disease progression. Hence, the laboratory parameters identified should be considered in clinical practice, which provide new insights into the identification of asymptomatic individuals and the prevention of virus transmission.
摘要：
无症状的SARS-CoV-2感染个体被认为在病毒传播中起主要作用。本研究旨在分析COVID-19无症状携带者的特征，以控制该病毒的传播。我们回顾性调查了648名连续受试者的临床特征，这些受试者被纳入研究并分为无症状携带者，轻度病例,普通案件,严重或危重病例，并通过Spearman相关和多元回归分析评估其对疾病严重程度的影响。进行了受试者工作特征曲线分析，以确定无症状COVID-19携带者诊断预测因子的实验室发现的最佳截止水平。在我们的研究中,我们共纳入了648名入院时受试者,平均年龄为45.61岁,其中男性345名,女性303名.白细胞，淋巴细胞，嗜酸性粒细胞,血小板,C反应蛋白,白细胞介素-6,CD3+,CD4+,和CD8+T淋巴细胞水平，各组红细胞沉降率差异显著(均p≤0.05)。疾病严重程度与CD3+呈负相关(r=-0.340;p<0.001),CD4+(r=-0.290;p=0.001)和CD8+(r=-0.322;p<0.001)T淋巴细胞水平。COVID-19无症状携带者的重要诊断预测因子包括血细胞，细胞因子,和T淋巴细胞亚群水平。炎症和免疫反应可能在疾病进展中起重要作用。因此，在临床实践中应考虑确定的实验室参数，这为识别无症状个体和预防病毒传播提供了新的见解。
