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Abstract：
OBJECTIVE: Our objective was to study the relationship of healthy vascular aging (HVA) with lifestyle and the components of metabolic syndrome. We also analyzed the differences between chronological age and heart age (HA) and vascular age (VA) in the Spanish adult population without cardiovascular disease.
METHODS: This descriptive cross-sectional study selected 501 individuals without cardiovascular disease (mean age, 55.9 years; 50.3% women) via random sampling stratified by age and sex. HA was estimated with the Framingham equation, whereas VA was estimated with the VaSera VS-1500 device. HVA was defined as a <5-year difference between the chronological age and the HA or VA and the absence of a vascular lesion, hypertension, and diabetes mellitus.
RESULTS: Compared with the chronological age, the mean HA and VA were 2.98±10.13 and 3.08±10.15 years lower, respectively. Smoking (OR, 0.23), blood pressure ≥ 130/85mmHg (OR, 0.11), altered baseline blood glucose (OR, 0.45), abdominal obesity (OR, 0.58), triglycerides ≥ 150mg/dL (OR, 0.17), and metabolic syndrome (OR, 0.13) decreased the probability of HVA estimated by HA; an active lifestyle (OR, 1.84) and elevated high-density lipoprotein-cholesterol (OR, 3.26) increased the probability of HVA estimated by HA. Smoking (OR, 0.45), blood pressure ≥ 130/85mmHg (OR, 0.26), altered baseline blood glucose (OR, 0.42), and metabolic syndrome (OR, 0.40) decreased the probability of HVA estimated by VA; abdominal obesity (OR, 1.81) had the opposite effect.
CONCLUSIONS: HA and VA were 3 years lower than the chronological age. HA was associated with tobacco consumption, physical activity, and the components of metabolic syndrome. Meanwhile, VA was associated with tobacco consumption, blood pressure, waist circumference, and altered baseline glycemia.
BACKGROUND: http://www.clinicaltrials.gov. Identifier: NCT02623894.
METHODS: This descriptive cross-sectional study selected 501 individuals without cardiovascular disease (mean age, 55.9 years; 50.3% women) via random sampling stratified by age and sex. HA was estimated with the Framingham equation, whereas VA was estimated with the VaSera VS-1500 device. HVA was defined as a <5-year difference between the chronological age and the HA or VA and the absence of a vascular lesion, hypertension, and diabetes mellitus.
RESULTS: Compared with the chronological age, the mean HA and VA were 2.98±10.13 and 3.08±10.15 years lower, respectively. Smoking (OR, 0.23), blood pressure ≥ 130/85mmHg (OR, 0.11), altered baseline blood glucose (OR, 0.45), abdominal obesity (OR, 0.58), triglycerides ≥ 150mg/dL (OR, 0.17), and metabolic syndrome (OR, 0.13) decreased the probability of HVA estimated by HA; an active lifestyle (OR, 1.84) and elevated high-density lipoprotein-cholesterol (OR, 3.26) increased the probability of HVA estimated by HA. Smoking (OR, 0.45), blood pressure ≥ 130/85mmHg (OR, 0.26), altered baseline blood glucose (OR, 0.42), and metabolic syndrome (OR, 0.40) decreased the probability of HVA estimated by VA; abdominal obesity (OR, 1.81) had the opposite effect.
CONCLUSIONS: HA and VA were 3 years lower than the chronological age. HA was associated with tobacco consumption, physical activity, and the components of metabolic syndrome. Meanwhile, VA was associated with tobacco consumption, blood pressure, waist circumference, and altered baseline glycemia.
BACKGROUND: http://www.clinicaltrials.gov. Identifier: NCT02623894.
摘要：
目的：我们的目的是研究健康血管老化（HVA）与生活方式和代谢综合征成分的关系。我们还分析了无心血管疾病的西班牙成年人口的实际年龄与心脏年龄（HA）和血管年龄（VA）之间的差异。
方法：这项描述性横断面研究选择了501名没有心血管疾病的个体（平均年龄，55.9岁；50.3%女性）通过随机抽样按年龄和性别分层。HA是用弗雷明汉方程估计的，而VA是用VaSeraVS-1500装置估计的。HVA定义为实际年龄与HA或VA之间的差异<5年，并且没有血管病变。高血压,和糖尿病。
结果：与实际年龄相比，平均HA和VA分别低2.98±10.13和3.08±10.15年，分别。吸烟(或,0.23),血压≥130/85mmHg（OR，0.11),基线血糖改变(OR，0.45),腹部肥胖（或，0.58),甘油三酯≥150mg/dL(OR，0.17),和代谢综合征(OR，0.13)降低了HA估计的HVA概率；积极的生活方式(OR，1.84）和高密度脂蛋白胆固醇升高（OR，3.26)增加了HA估计的HVA的概率。吸烟(或,0.45),血压≥130/85mmHg（OR，0.26),基线血糖改变(OR，0.42),和代谢综合征(OR，0.40)降低了VA估计的HVA的概率；腹型肥胖(OR，1.81）具有相反的效果。
结论：HA和VA比实际年龄低3岁。HA与烟草消费有关，身体活动,和代谢综合征的组成部分。同时,VA与烟草消费有关，血压,腰围,和改变基线血糖。
背景：http://www.临床试验.gov.标识符：NCT02623894。
方法：这项描述性横断面研究选择了501名没有心血管疾病的个体（平均年龄，55.9岁；50.3%女性）通过随机抽样按年龄和性别分层。HA是用弗雷明汉方程估计的，而VA是用VaSeraVS-1500装置估计的。HVA定义为实际年龄与HA或VA之间的差异<5年，并且没有血管病变。高血压,和糖尿病。
结果：与实际年龄相比，平均HA和VA分别低2.98±10.13和3.08±10.15年，分别。吸烟(或,0.23),血压≥130/85mmHg（OR，0.11),基线血糖改变(OR，0.45),腹部肥胖（或，0.58),甘油三酯≥150mg/dL(OR，0.17),和代谢综合征(OR，0.13)降低了HA估计的HVA概率；积极的生活方式(OR，1.84）和高密度脂蛋白胆固醇升高（OR，3.26)增加了HA估计的HVA的概率。吸烟(或,0.45),血压≥130/85mmHg（OR，0.26),基线血糖改变(OR，0.42),和代谢综合征(OR，0.40)降低了VA估计的HVA的概率；腹型肥胖(OR，1.81）具有相反的效果。
结论：HA和VA比实际年龄低3岁。HA与烟草消费有关，身体活动,和代谢综合征的组成部分。同时,VA与烟草消费有关，血压,腰围,和改变基线血糖。
背景：http://www.临床试验.gov.标识符：NCT02623894。
