■在这项研究中,我们分析了35-75岁西班牙人群中体力活动和久坐的生活方式与血管衰老之间的关系。
■开展了一项横断面研究,招募了501名35-75岁的受试者。用加速度计(ActigraphGTX3)测量一周的体力活动和久坐时间。我们通过SphygmoCor®设备测量了颈动脉-股动脉脉搏波速度(cfPWV),并通过超声(SonositeMicromax®)测量了颈动脉内中膜厚度(cIMT)。如文献中所述计算血管老化指数(VAI)。根据cfPWV和VAI的年龄和性别,考虑第25和第75百分位数定义血管老化,血管损伤的存在,2型糖尿病或动脉高血压。个人分为三组:健康,正常,和早期血管老化。
■样本的平均年龄为55.90±14.24岁,50%是女性。总体力活动与cfPWV(β=-0.454)和VAI(β=-1.845)呈负相关。同样,每天的步数与cfPWV(β=-0.052)和VAI(β=-0.216)呈负相关,静坐时间与cfPWV(β=0.028)和VAI(β=0.117)呈正相关。在性别分析中,结果显示类似的值。对于cfPWV,分类为早期血管衰老(EVA)的受试者与分类为健康血管衰老(HVA)的受试者的总体力活动的比值比(OR)为0.521(95%置信区间[CI]0.317至0.856),VAI为0.565(95%CI0.324至0.986)。就每天的步数而言,cfPWV的OR为0.931(95%CI0.875~0.992),VAI的OR为0.916(95%CI0.847~0.990),静坐时间cfPWV的OR为1.042(95%CI1.011~1.073),VAI的OR为1.037(95%CI1.003~1.072).使用cfPWV分类为剧烈体力活动的受试者的OR为0.196(95%CI0.041至0.941),使用VAI分类为0.161(95%CI0.032至0.820)。在性别分析中,结果显示,当使用cfPWV时,男性与VAI定义血管老化时,女性与CFPWV相关.
■这项研究的结果表明,进行体育锻炼的时间越多,久坐的时间越少,动脉僵硬度越低,发生早期血管老化的概率越低。
■该研究已在ClinicalTrials.gov上注册(编号:NCT02623894)。
UNASSIGNED: In this study we analyzed the association between physical activity and sedentary lifestyle with vascular aging in Spanish populations aged 35-75 years.
UNASSIGNED: A cross-sectional study was developed, in which 501 subjects aged 35-75 years were recruited. Physical activity and sedentary time were measured with an accelerometer (Actigraph GTX3) for a week. We measured carotid-femoral pulse wave velocity (cfPWV) by a Sphygmo Cor® device and carotid intima-media thickness (cIMT) by ultrasound (Sonosite Micromax®). The vascular aging index (VAI) was calculated as described in the literature. Vascular aging was defined considering the 25th and 75th percentiles by age and sex of cfPWV and VAI, presence of vascular injury, type-2 diabetes mellitus or arterial hypertension. Individuals were classified into three groups: healthy, normal, and early vascular aging.
UNASSIGNED: The mean age of the sample was 55.90 ± 14.24 years, 50% being women. Total physical activity was negatively associated with cfPWV ( β = -0.454) and VAI ( β = -1.845). Similarly, the number of steps per day obtained a negative association with cfPWV ( β = -0.052) and VAI ( β = -0.216), while sedentary time showed a positive association with cfPWV ( β = 0.028) and VAI ( β = 0.117). In the analysis by sex, the results showed similar values. The odds ratio (OR) of total physical activity of subjects classified as early vascular aging (EVA) with regarding those classified as healthy vascular aging (HVA) was 0.521 (95% confidence interval [CI] 0.317 to 0.856) for cfPWV, and 0.565 (95% CI 0.324 to 0.986) for VAI. In terms of the number of steps per day, the OR was 0.931 (95% CI 0.875 to 0.992) for cfPWV and 0.916 (95% CI 0.847 to 0.990) for VAI and for sedentary time the OR was 1.042 (95% CI 1.011 to 1.073) for cfPWV and 1.037 (95% CI 1.003 to 1.072) for VAI. The OR of subjects classified as vigorous physical activity was 0.196 (95% CI 0.041 to 0.941) using cfPWV and 0.161 (95% CI 0.032 to 0.820) using VAI. In the analysis by sex, the results showed an association in men when cfPWV was used and an association in women when VAI was used to define vascular aging.
UNASSIGNED: The results of this study indicate that the more time spent performing physical activity and the less sedentary time, the lower the arterial stiffness and the probability of developing early vascular aging.
UNASSIGNED: The study was registered in ClinicalTrials.gov (number: NCT02623894).