肝病中的嘌呤能信号 : 病理功能和治疗机会。
关键词: A1, adenosine receptor A1 A2A, adenosine receptor A2A A2B, adenosine receptor A2B A3, adenosine receptor A3 AIH, autoimmune hepatitis ALT, alanine aminotransferase APAP, acetaminophen APCP, α,β-methylene ADP Adenosine receptors BDL, bile duct ligation CCl4, carbon tetrachloride CD73, ecto-5ʹ-nucleotidase ConA, concanavalin A DCs, dendritic cells DMN, dimethylnitrosamine Ecto-5ʹ-nucleotidase Ectonucleoside triphosphate diphosphohydrolases 1 HCC, hepatocellular carcinoma HFD, high-fat diet HGF, hepatocyte growth factor HSCs, hepatic stellate cells IFN, interferon IL-, interleukin- IPC, ischaemic preconditioning IR, ischaemia-reperfusion Liver MAPK, mitogen-activating protein kinase MCDD, methionine- and choline-deficient diet MHC, major histocompatibility complex NAFLD, non-alcoholic fatty liver disease NK, natural killer NKT, natural killer T NTPDases, ectonucleoside triphosphate diphosphohydrolases Nucleotide receptors P1, purinergic type 1 P2, purinergic type 2 PBC, primary biliary cholangitis PH, partial hepatectomy PKA, protein kinase A PPADS, pyridoxal-phosphate-6-azophenyl-2′,4′-disulphonate Purinergic signals ROS, reactive oxygen species TAA, thioacetamide TNF, tumour necrosis factor Tregs, regulatory T cells VEGF, vascular endothelial growth factor
来 源:
DOI:10.1016/j.jhepr.2020.100165
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