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Abstract：
In a woman with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) followed for 15 years, we observed magnetic resonance imaging white matter hyperintensities that vanished in the anterior temporal poles while the brain volume decreased unexpectedly. These imaging changes were transient and detected when the patient was being treated by valproic acid for stabilizing mood disturbances. This intriguing case supports that mechanisms underlying white matter hyperintensities can vary from one brain area to another and that important modifications of water influx into the brain tissue might be involved in some imaging features of CADASIL.
摘要：
在患有皮质下梗死和白质脑病（CADASIL）的常染色体显性脑病的女性中，随访15年，我们观察到磁共振成像白质高强度在颞前极消失，而脑容量意外减少。这些影像学变化是短暂的，并在患者接受丙戊酸治疗以稳定情绪障碍时检测到。这个有趣的案例支持白质高强度的机制可能因大脑区域而异，并且流入脑组织的水的重要变化可能涉及CADASIL的某些成像特征。
