Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient.

• 发表时间: Sep 2020 8
• 来源期刊: BMJ Case Rep
• DOI: 10.1136/bcr-2020-236396
• PMID: 32907868
• 文章类型: Case Reports
• 作者列表: Asif AA,Roy M,Ahmad S

关键词: bone and joint infections; drugs: infectious diseases; orthopaedics

Mesh: Aged; Anti-Bacterial Agents / pharmacology therapeutic use; Arthritis, Infectious / diagnosis microbiology therapy; Arthroscopy; DNA, Bacterial / isolation & purification; Debridement; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; High-Throughput Nucleotide Sequencing; Humans; Knee Joint / diagnostic imaging microbiology surgery; Magnetic Resonance Imaging; Meniscectomy; Osteoarthritis, Knee / diagnosis microbiology therapy; Polymerase Chain Reaction; Sequence Analysis, DNA; Severity of Illness Index; Synovectomy; Treatment Outcome; Ureaplasma / drug effects genetics isolation & purification; Ureaplasma Infections / diagnosis microbiology therapy

Abstract

Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.