{Reference Type}: Case Reports {Title}: Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient. {Author}: Asif AA;Roy M;Ahmad S; {Journal}: BMJ Case Rep {Volume}: 13 {Issue}: 9 {Year}: Sep 2020 8 暂无{DOI}: 10.1136/bcr-2020-236396 {Abstract}: Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.