DNA samples from 92 patients and 156 healthy controls collected from two medical centers in Riyadh, Saudi Arabia were analyzed for four regions located at X-chromosome using the Investigator® Argus X-12 QS Kit.
The results demonstrated that microvariant alleles of (DXS7132, DXS10146, HPRTB, DXS10134, and DXS10135) are overrepresented in the BPH group (p < 0.00001). Allele 28 of DXS10135 and allele 15 of DXS7423 could have a protective effect, OR 0.229 (95%CI, 0.066-0.79); and OR 0.439 (95%CI, 0.208-0.925). On the other hand, patients carrying allele 23 of DXS10079 and allele 26 of DXS10148 presented an increased risk to PrCa OR 4.714 (95%CI, 3.604-6.166).
The results are in concordance with the involvement of the X chromosome in PrCa and BPH development. STR allele studies may add further information from the definition of a genetic profile of PrCa resistance or susceptibility. As TBL1, AR, LDOC1, and RPL10 genes are located at regions Xp22.31, Xq11.2-12, Xq26.2, and Xq28, respectively, these genes could play an essential role in PrCa or BPH.
从利雅得的两个医疗中心收集的92名患者和156名健康对照的DNA样本,使用Investigator®ArgusX-12QS试剂盒分析沙特阿拉伯位于X染色体的四个区域。
结果表明,(DXS7132,DXS10146,HPRTB,DXS10134和DXS10135)在BPH组中代表过多(p<0.00001)。DXS10135的等位基因28和DXS7423的等位基因15可能具有保护作用,或0.229(95CI,0.066-0.79);和0.439(95CI,0.208-0.925)。另一方面,携带DXS10079等位基因23和DXS10148等位基因26的患者出现PrCaOR4.714的风险增加(95CI,3.604~6.166).
结果与X染色体参与PrCa和BPH发育是一致的。STR等位基因研究可以从PrCa抗性或易感性的遗传谱的定义中添加进一步的信息。作为TBL1,AR,LDOC1和RPL10基因分别位于区域Xp22.31,Xq11.2-12,Xq26.2和Xq28,这些基因可能在PrCa或BPH中起重要作用。