Azithromycin, minocycline, moxifloxacin and spectinomycin failure in a case with persistent Mycoplasma genitalium infection in Guangzhou, China.

阿奇霉素,米诺环素,广州地区持续生殖器支原体感染的莫西沙星和大观霉素失败 ，中国。

• 影响指数: 1.456
• 发表时间: 10 2020
• 来源期刊: Int J STD AIDS
• DOI: 10.1177/0956462420905269
• PMID: 32842908
• 文章类型: Case Reports
• 中科院分区: Q4
• 方向: 医学
• 作者列表: Yang L,Ke W

关键词: Asia; Mycoplasma genitalium; Non-gonococcal urethritis; antibiotic

Mesh: Anti-Bacterial Agents / pharmacology therapeutic use; Azithromycin / pharmacology therapeutic use; DNA Gyrase / genetics; DNA, Bacterial / genetics; Humans; Middle Aged; Minocycline / pharmacology therapeutic use; Moxifloxacin / pharmacology therapeutic use; Mycoplasma Infections / drug therapy genetics microbiology; Mycoplasma genitalium / drug effects genetics isolation & purification; RNA, Ribosomal, 23S / genetics; Sequence Analysis, DNA; Spectinomycin / pharmacology therapeutic use; Treatment Failure; Urethritis / drug therapy microbiology

Abstract

We report a case of Mycoplasma genitalium-positive non-gonococcal urethritis who failed to respond to multiple different courses of antibiotics including azithromycin, minocycline, moxifloxacin and spectinomycin. Extracted M. genitalium DNA from urethral swabs obtained from the patient harbored mutations of 23S rRNA, parC and gyrA. Microbiological cure was eventually achieved by a 14-day course of doxycycline.

摘要

我们报告了一例生殖器支原体阳性非淋菌性尿道炎，对包括阿奇霉素在内的多个不同疗程的抗生素均无反应，米诺环素,莫西沙星和大观霉素.从患有23SrRNA突变的患者获得的尿道拭子中提取的生殖支原体DNA，parC和gyrA.通过14天的多西环素疗程最终实现了微生物治疗。