泛素样修饰剂 FAT10 抑制视网膜 PDE6 活性并介导其蛋白酶体降解。
关键词: AIPL1 FAT10 PDE6 cell culture chaperone cyclic GMP (cGMP) phosphodiesterases photoreceptor proteasome protein processing protein stability protein turnover retina retinal degeneration ubiquitin-like protein ubiquitylation (ubiquitination)
Mesh : Adaptor Proteins, Signal Transducing / chemistry genetics metabolism Amino Acid Motifs Animals Catalytic Domain Cyclic GMP / metabolism Cyclic Nucleotide Phosphodiesterases, Type 6 / chemistry metabolism HEK293 Cells Humans Mice Mice, Inbred C57BL Mutagenesis, Site-Directed Proteasome Endopeptidase Complex / chemistry metabolism Proteasome Inhibitors / pharmacology Protein Binding Proteolysis / drug effects RNA, Messenger / metabolism Recombinant Proteins / biosynthesis chemistry isolation & purification Retina / metabolism Ubiquitin / metabolism Ubiquitins / chemistry genetics metabolism
来 源:
DOI:10.1074/jbc.RA120.013873
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