NoeliaLander致力于美国锥虫中的细胞信号传导,并研究环磷酸腺苷(cAMP)微域在环境感知和分化中的作用。在这个影响范围内,Lander博士在不同的真核模型中回顾了三篇研究文章,这些文章影响了她对克氏锥虫cAMP信号调节的看法,查加斯病的病因。文章“FRET生物传感器揭示了β-肾上腺素能靶点的cAMP纳米结构域,决定了心脏收缩力的精确调节”(N.C.Surdo,M.Berrera,A.Koschinski,M.布雷西亚,etal.,NatCommun8:15031,2017,https://doi.org/10.1038/ncomms15031),“循环AMP信号和葡萄糖代谢介导非洲锥虫的pH值出租车”(S.肖,S.Knusel,D.Abbühl,A.Naguleswaran,etal.,NatCommun13:603,2022,https://doi.org/10.1038/s41467-022-28293-w),和“在贾第鞭毛虫中,腺苷酸环化酶AC2依赖性cAMP信号介导了对刺激的感觉”(H。W.Shih,G.C.M.唉,A.R.Paredez,NatCommun14:7245,2023,https://doi.org/10.1038/s41467-023-43028-1)影响了她目前的假设,即cAMP信号是响应于环境线索而产生的,导致鞭毛尖端和T.cruzi的收缩液泡复合物,cAMP介导发育进展的关键细胞过程的结构。
Noelia Lander works on cell signaling in American trypanosomes and studies the role of cyclic adenosine monophosphate (cAMP) microdomains in environmental sensing and differentiation. In this mSphere of Influence, Dr. Lander reflects on three research articles in different eukaryotic models that had impacted on the way she thinks about the regulation of cAMP signals in Trypanosoma cruzi, the etiologic agent of Chagas disease. The articles \"FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility\" (N. C. Surdo, M. Berrera, A. Koschinski, M. Brescia, et al., Nat Commun 8:15031, 2017, https://doi.org/10.1038/ncomms15031), \"Cyclic AMP signaling and glucose metabolism mediate pH taxis by African trypanosomes\" (S. Shaw, S. Knüsel, D. Abbühl, A. Naguleswaran, et al., Nat Commun 13:603, 2022, https://doi.org/10.1038/s41467-022-28293-w), and \"Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia\" (H. W. Shih, G. C. M. Alas, and A. R. Paredez, Nat Commun 14:7245, 2023, https://doi.org/10.1038/s41467-023-43028-1) influenced her current hypothesis that cAMP signals are generated in response to environmental cues leading to changes in membrane fluidity at the flagellar tip and the contractile vacuole complex of T. cruzi, structures where cAMP mediates key cellular processes for developmental progression.