PDF(Pubmed)
Abstract：
BACKGROUND: We perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race.
METHODS: The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center.
RESULTS: Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks.
CONCLUSIONS: Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.
METHODS: The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center.
RESULTS: Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks.
CONCLUSIONS: Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.
摘要：
背景：我们进行了全表型扫描，以确定医学表型中与COVID-19易感性和预后相关的预先存在的疾病，以及它们如何因种族而异。
方法：该研究包括2020年3月10日至9月2日在一家大型学术医学中心进行COVID-19检测/阳性的53,853名患者。
结果：与住院密切相关的既往疾病是肾衰竭，肺心病,和呼吸衰竭。非西班牙裔白人的造血状况与ICU入院/死亡率相关，精神障碍与非西班牙裔白人的死亡率相关。非西班牙裔黑人的循环系统和泌尿生殖系统状况与非ICU入院/死亡率相关。
结论：了解与COVID-19结局相关的预先存在的临床诊断表明，需要进行有针对性的筛查，以支持特定的脆弱人群改善疾病预防和医疗保健服务。
方法：该研究包括2020年3月10日至9月2日在一家大型学术医学中心进行COVID-19检测/阳性的53,853名患者。
结果：与住院密切相关的既往疾病是肾衰竭，肺心病,和呼吸衰竭。非西班牙裔白人的造血状况与ICU入院/死亡率相关，精神障碍与非西班牙裔白人的死亡率相关。非西班牙裔黑人的循环系统和泌尿生殖系统状况与非ICU入院/死亡率相关。
结论：了解与COVID-19结局相关的预先存在的临床诊断表明，需要进行有针对性的筛查，以支持特定的脆弱人群改善疾病预防和医疗保健服务。
