%0 Preprint
%T A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.
%A Salvatore M
%A Gu T
%A Mack JA
%A Sankar SP
%A Patil S
%A Valley TS
%A Singh K
%A Nallamothu BK
%A Kheterpal S
%A Lisabeth L
%A Fritsche LG
%A Mukherjee B
%J medRxiv
%V 0
%N 0
%D Feb 2021 20
%M 32793923
暂无%R 10.1101/2020.06.29.20141564
%X BACKGROUND: We perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race.
METHODS: The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center.
RESULTS: Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks.
CONCLUSIONS: Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.