{Reference Type}: Preprint
{Title}: A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine.
{Author}: Salvatore M;Gu T;Mack JA;Sankar SP;Patil S;Valley TS;Singh K;Nallamothu BK;Kheterpal S;Lisabeth L;Fritsche LG;Mukherjee B;
{Journal}: medRxiv
{Volume}: 0
{Issue}: 0
{Year}: Feb 2021 20
暂无{DOI}: 10.1101/2020.06.29.20141564
{Abstract}: <B>BACKGROUND: </B>We perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race.<BR><B>METHODS: </B>The study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center.<BR><B>RESULTS: </B>Pre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks.<BR><B>CONCLUSIONS: </B>Understanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.