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Abstract：
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has established distinct diagnostic categories for reporting cytopathological findings, and each is associated with a defined risk of malignancy (ROM). However, the ROM is applied at the overall category level and is not specific for particular morphological entities within a category. Here, the diagnostic performance of the MSRSGC for pleomorphic adenoma (PA) and Warthin tumor (WT) is reported.
The pathology archives of 11 institutions from 4 countries were retrospectively searched to identify all salivary gland fine-needle aspiration (FNA) biopsies with a differential or definitive diagnosis of PA or WT and all resection specimens with a diagnosis of PA or WT; only paired cases were included. All FNA diagnoses were retrospectively classified according to the MSRSGC.
A total of 1250 cases met the inclusion criteria, and they included 898 PA cases and 352 WT cases. The ROM in the benign neoplasm category was 3.0% and 1.3% for cases with a differential or definitive diagnosis of PA and WT, respectively. The ROM in the salivary gland neoplasm with uncertain malignant potential (SUMP) category was 2.7% and 18.8% for PA and WT, respectively (P = .0277). The diagnostic accuracy for PA and WT was 95.1% and 96.1%, respectively.
The diagnostic accuracy for PA and WT on FNA is high. Furthermore, these findings highlight the difference in the ROMs associated with 2 specific differential diagnoses in the SUMP category: basaloid neoplasms and oncocytoid neoplasms.
The pathology archives of 11 institutions from 4 countries were retrospectively searched to identify all salivary gland fine-needle aspiration (FNA) biopsies with a differential or definitive diagnosis of PA or WT and all resection specimens with a diagnosis of PA or WT; only paired cases were included. All FNA diagnoses were retrospectively classified according to the MSRSGC.
A total of 1250 cases met the inclusion criteria, and they included 898 PA cases and 352 WT cases. The ROM in the benign neoplasm category was 3.0% and 1.3% for cases with a differential or definitive diagnosis of PA and WT, respectively. The ROM in the salivary gland neoplasm with uncertain malignant potential (SUMP) category was 2.7% and 18.8% for PA and WT, respectively (P = .0277). The diagnostic accuracy for PA and WT was 95.1% and 96.1%, respectively.
The diagnostic accuracy for PA and WT on FNA is high. Furthermore, these findings highlight the difference in the ROMs associated with 2 specific differential diagnoses in the SUMP category: basaloid neoplasms and oncocytoid neoplasms.
摘要：
米兰唾液腺细胞病理学报告系统（MSRSGC）建立了不同的诊断类别，用于报告细胞病理学发现，每个都与定义的恶性肿瘤（ROM）风险相关。然而,ROM应用于整个类别级别，而不是特定于类别中的特定形态实体。这里,据报道,MSRSGC对多形性腺瘤(PA)和Warthin瘤(WT)的诊断性能.
回顾性检索了来自4个国家的11个机构的病理学档案，以确定所有唾液腺细针穿刺（FNA）活检与PA或WT的鉴别或明确诊断，以及所有切除标本与PA或WT的诊断；仅包括配对病例。所有FNA诊断均根据MSRSGC进行回顾性分类。
共有1250例符合纳入标准,其中包括898例PA病例和352例WT病例。对于PA和WT的鉴别或明确诊断的病例，良性肿瘤类别的ROM为3.0％和1.3％。分别。对于PA和WT，具有不确定恶性潜能（SUMP）类别的唾液腺肿瘤中的ROM分别为2.7％和18.8％，分别为（P=0.0277）。PA和WT的诊断准确率分别为95.1％和96.1％，分别。
FNA上的PA和WT的诊断准确性很高。此外，这些发现强调了与SUMP类别中2种特定鉴别诊断相关的ROM的差异:基底细胞样肿瘤和肿瘤细胞样肿瘤.
回顾性检索了来自4个国家的11个机构的病理学档案，以确定所有唾液腺细针穿刺（FNA）活检与PA或WT的鉴别或明确诊断，以及所有切除标本与PA或WT的诊断；仅包括配对病例。所有FNA诊断均根据MSRSGC进行回顾性分类。
共有1250例符合纳入标准,其中包括898例PA病例和352例WT病例。对于PA和WT的鉴别或明确诊断的病例，良性肿瘤类别的ROM为3.0％和1.3％。分别。对于PA和WT，具有不确定恶性潜能（SUMP）类别的唾液腺肿瘤中的ROM分别为2.7％和18.8％，分别为（P=0.0277）。PA和WT的诊断准确率分别为95.1％和96.1％，分别。
FNA上的PA和WT的诊断准确性很高。此外，这些发现强调了与SUMP类别中2种特定鉴别诊断相关的ROM的差异:基底细胞样肿瘤和肿瘤细胞样肿瘤.
