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Abstract：
Metabolic syndrome (MetS), a constellation of related metabolic risk factors, is a common comorbidity associated with cognitive difficulty in people living with HIV (PLWH). Neurobehavioral disturbances (e.g., behavioral manifestations of frontal-subcortical dysfunction) are also prevalent in HIV, yet the role MetS might play in HIV-associated neurobehavioral disturbances is unknown. Thus, we examined the link between MetS and neurobehavioral disturbances in PLWH. Participants included 215 adults (117 PLWH, 98 HIV-uninfected), aged 36 to 65 years, from a cohort study at the University of California San Diego. Using the Frontal Systems Behavior Scale, we captured neurobehavioral disturbances (apathy, disinhibition, and executive dysfunction). MetS was defined by the National Cholesterol Education Program\'s Adult Treatment Panel-III criteria. Covariates examined included demographic, neurocognitive impairment, and psychiatric characteristics. When controlling for relevant covariates, both HIV serostatus and MetS were independently associated with greater apathy and executive dysfunction. HIV, but not MetS, was associated with greater disinhibition. The present findings suggest an additive effect of HIV and MetS on specific neurobehavioral disturbances (apathy and executive dysfunction), underscoring the importance of identifying and treating both HIV and MetS to lessen central nervous system burden among PLWH.
摘要：
代谢综合征（MetS），一系列相关的代谢危险因素，是与HIV感染者（PLWH）的认知困难相关的常见合并症。神经行为障碍(例如，额叶-皮质下功能障碍的行为表现）在HIV中也很普遍，然而,MetS在HIV相关神经行为障碍中可能发挥的作用尚不清楚.因此，我们研究了在PLWH中MetS和神经行为障碍之间的联系。参与者包括215名成年人（117PLWH，98未感染艾滋病毒），年龄在36至65岁之间，来自加州大学圣地亚哥分校的一项队列研究。使用额叶系统行为量表，我们捕捉到了神经行为障碍(冷漠，去抑制,和执行功能障碍)。MetS由国家胆固醇教育计划的成人治疗小组III标准定义。检查的协变量包括人口统计，神经认知障碍，和精神病学特征。当控制相关协变量时，HIV血清状态和MetS均与更大的冷漠和执行功能障碍独立相关.艾滋病毒,但不是MetS,与更大的去抑制有关。本研究结果表明，HIV和MetS对特定的神经行为障碍（冷漠和执行功能障碍）具有累加作用，强调识别和治疗HIV和MetS以减轻PLWH中枢神经系统负担的重要性。
