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Abstract：
Integrins mediate adhesion of cells to substrates and maintain tissue integrity by facilitating mechanotransduction between cells, the extracellular matrix, and gene expression in the nucleus. Changes in integrin expression in corneal epithelial cells and corneal endothelial cells impacts their adhesion to the epithelial basement membrane (EpBM) and Descemet\'s membrane, respectively. Integrins also play roles in assembly of basement membranes by both activating TGFβ1 and other growth factors. Over the past two decades, this knowledge has been translated into methods to grow corneal epithelial and endothelial cells in vitro for transplantation in the clinic thereby transforming clinical practice and quality of life for patients. Current knowledge on the expression and function of the integrins that mediate adhesion to the basement membrane expressed by corneal epithelial and endothelial cells in health and disease is summarized. This is the first review to discuss similarities and differences in the integrins expressed by both cell types.
摘要：
整合素通过促进细胞之间的机械转导来介导细胞与基质的粘附并维持组织完整性。细胞外基质，和细胞核中的基因表达。角膜上皮细胞和角膜内皮细胞中整合素表达的变化影响其与上皮基底膜（EpBM）和Descemet膜的粘附，分别。整合素还通过激活TGFβ1和其他生长因子在基底膜的组装中发挥作用。在过去的二十年里，这些知识已转化为体外培养角膜上皮和内皮细胞的方法，用于临床移植，从而改变临床实践和患者的生活质量。总结了在健康和疾病中介导角膜上皮和内皮细胞表达的与基底膜粘附的整合素的表达和功能的最新知识。这是讨论两种细胞类型表达的整合素的相似性和差异性的第一个综述。
