使用眼前节光学相干断层扫描(ASOCT)和术中OCT(iOCT)比较年龄较大的和年龄较小的原发性先天性青光眼(PCG)患儿的后角膜形态。分别。
在这项比较研究中,将年龄较大的PCG儿童的ASOCT与未治疗的年轻PCG患者的iOCT进行比较。研究了两组在后角膜形态方面的差异。
在接受治疗的年龄较大(年龄:72-300个月)的儿童(87只眼)中观察到的后角膜形态模式包括Descemet膜(DM)异常(70%),增厚DM(35%),前房内孪生突起(92%),和DM脱离(26%)。前Descemet层(PDL)(28%)内的变化包括增厚,休息,和分遣队。当在治疗组中分析时,Haab纹的程度与DM/PDL复合物的厚度相关(P=0.008)。相比之下,在未治疗组(n=53眼,年龄1-63个月),后角膜改变仅限于DM/PDL复合体的弥漫性高反射率,没有DM的眼泪。
与未经治疗的PCG眼相比,接受治疗的年龄较大的儿童的后角膜变厚,Haab的条纹变得更加有限,可能反映了随着时间的推移后角膜的愈合反应。
To compare posterior corneal morphology between older treated and younger untreated children with primary congenital glaucoma (PCG) using anterior segment optical coherence tomography (ASOCT) and intraoperative OCT (iOCT), respectively.
In this comparative study, ASOCT of older PCG children were compared with iOCT of younger untreated PCG patients. Differences between the two groups with respect to posterior corneal morphology were studied.
Observed morphological patterns within posterior cornea in older treated (age: 72-300 months) children (87 eyes) included Descemet\'s membrane (DM) excrescences (70%), thickened DM (35%), intracameral twin protuberances (92%), and DM detachment (26%). Changes within pre-Descemet\'s layer (PDL) (28%) included thickening, breaks, and detachments. Extent of Haab\'s striae was associated with thickness of DM/PDL complex (P = 0.008) when analyzed in the treated group. In contrast, in the untreated group (n = 53 eyes, age 1-63 months), posterior corneal changes were limited to diffuse hyper-reflectivity of the DM/PDL complex, with absence of DM tears.
Posterior cornea thickens and Haab\'s striae become more circumscribed in eyes of older treated children compared to untreated PCG eyes, probably reflecting a healing response of posterior cornea over time.