激素对肝脏再生的贡献。
关键词: CDK, cyclin-dependent kinase EGF, epidermal growth factor EGFR, EGF receptor ERK, extracellular signal-regulated kinase FAH, fumarylacetoacetate hydrolase GH, growth hormone Ghr-/-, growth hormone receptor gene knockout HGF, hepatocyte growth factor HNF, hepatocyte nuclear factor HPC, hepatic progenitor cell IGF, insulinlike growth factor IL, interleukin IR, insulin receptor InsP3, inositol 1,4,5-trisphosphate JNK, JUN N-terminal kinase LDLT, living donor liver transplant LRP, low-density lipoprotein-related protein MAPK, mitogen-activated protein kinase NF-κβ, nuclear factor κβ NOS, nitric oxide synthase NTBC, 2-nitro-4-trifluoro-methyl-benzoyl-1,3-cyclohexanedione PCNA, proliferating cell nuclear antigen PCR, polymerase chain reaction PH, partial hepatectomy PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase PKB, protein kinase B PTU, 6-n-propyl-2-thiouracil ROS, reactive oxygen species STAT, signal transducer and activator of transcription T3, triiodothyronine TGF, transforming growth factor TNF, tumor necrosis factor TR, thyroid receptor hESC, human embryonic stem cell hiPSC, human induced pluripotent stem cells mRNA, messenger RNA mTOR, mammalian target of rapamycin
来 源:
DOI:10.1016/j.mayocpiqo.2020.02.001
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