关键词: CRC therapy colon cancer stem cells gut microbiota phytochemicals

Mesh : Animals Carcinogenesis Colon / microbiology pathology Colonic Neoplasms / drug therapy microbiology Diet Disease Progression Epigenesis, Genetic Flavonoids / chemistry Gastrointestinal Microbiome Humans Mice Neoplastic Stem Cells / metabolism Neovascularization, Pathologic Oxidative Stress Phytochemicals / therapeutic use Phytotherapy Polyphenols / chemistry Signal Transduction

来  源:   DOI:10.3390/ijms21113976   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Colorectal cancer (CRC) is a fatal disease caused by the uncontrolled propagation and endurance of atypical colon cells. A person\'s lifestyle and eating pattern have significant impacts on the CRC in a positive and/or negative way. Diet-derived phytochemicals modulate the microbiome as well as targeting colon cancer stem cells (CSCs) that are found to offer significant protective effects against CRC, which were organized in an appropriate spot on the paper. All information on dietary phytochemicals, gut microbiome, CSCs, and their influence on CRC were accessed from the various databases and electronic search engines. The effectiveness of CRC can be reduced using various dietary phytochemicals or modulating microbiome that reduces or inverses the progression of a tumor as well as CSCs, which could be a promising and efficient way to reduce the burden of CRC. Phytochemicals with modulation of gut microbiome continue to be auspicious investigations in CRC through noticeable anti-tumorigenic effects and goals to CSCs, which provides new openings for cancer inhibition and treatment.
摘要:
结直肠癌(CRC)是由非典型结肠细胞的不受控制的繁殖和耐力引起的致命疾病。一个人的生活方式和饮食习惯对CRC有积极和/或消极的影响。饮食衍生的植物化学物质调节微生物组以及靶向结肠癌干细胞(CSCs),这些细胞被发现对CRC具有显著的保护作用。它们被组织在纸上的适当位置。所有关于膳食植物化学物质的信息,肠道微生物组,CSCs,它们对CRC的影响是从各种数据库和电子搜索引擎中获取的。使用各种膳食植物化学物质或调节微生物组可以降低CRC的有效性,从而减少或逆转肿瘤以及CSC的进展,这可能是减轻CRC负担的一种有希望和有效的方法。通过明显的抗肿瘤作用和对CSC的目标,具有调节肠道微生物组的植物化学物质继续是CRC的吉祥研究,这为癌症抑制和治疗提供了新的机会。
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