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Abstract：
To investigate the seroepidemiological features of enterovirus D68 (EV-D68) in the healthy population from 2012 to 2017 in Beijing, China. A retrospective cross-sectional investigation was conducted using serum specimens collected from healthy individuals in Beijing from 2012 to 2017. These samples were tested for neutralization antibodies (NtAbs) against EV-D68. The sera from six EV-D68 infected patients in the acute or convalescent phase were used to determine the protection level of NtAbs against EV-D68. The geometric means of the titers (GMT) of EV-D68 NtAbs in 2012 and 2017 were 92.82 and 242.91, respectively; the seroprevalences of EV-D68 were 89.43% and 98.43%, respectively. The GMT reached its peak in the 11 to 15 age group in 2012, while in 16 to 20 age group in 2017. We also observed that EV-D68 NtAbs titers of six sera from the acute phase were all less than equal to 1:64 and that of three sera from the convalescent phase were all more than 1:64. Anti-EV-D68 NtAbs in the population remained low from 2012 to 2016 but increased significantly in 2017. Although most of the EV-D68 infections remain undetected in Beijing, the risk of a large outbreak of EV-D68 exists and should be taken seriously.
摘要：
调查2012-2017年北京市健康人群肠道病毒D68(EV-D68)血清流行病学特征,中国。采用2012-2017年北京地区健康体检者血清标本进行回顾性横断面调查。测试这些样品针对EV-D68的中和抗体(NtAb)。来自急性或恢复期的六名EV-D68感染患者的血清用于确定NtAbs对EV-D68的保护水平。2012年和2017年EV-D68NtAb滴度（GMT）的几何平均值分别为92.82和242.91；EV-D68的血清阳性率分别为89.43％和98.43％，分别。GMT在2012年的11至15岁年龄段达到峰值，而在2017年的16至20岁年龄段达到峰值。我们还观察到，急性期6份血清的EV-D68NtAbs滴度均小于等于1:64，恢复期3份血清的EV-D68NtAbs滴度均大于1:64。从2012年到2016年，人口中的抗EV-D68NtAbs仍然很低，但在2017年显著增加。尽管大多数EV-D68感染在北京仍未被发现，EV-D68大范围爆发的风险存在，应引起重视。
