RESULTS: This comparative study was carried out in four UK hospitals. Forty-five patients with anterior STEMI presenting within 12 h of symptom onset received pPCI plus PiCSO (initiated after reperfusion; n = 45) and were compared with a propensity score-matched control cohort from INFUSE-AMI (n = 80). Infarct size (% of LV mass, median [interquartile range]) measured by cardiac magnetic resonance (CMR) at day 5 was significantly lower in the PiCSO group (14.3% [95% CI 9.2-19.4%] vs. 21.2% [95% CI 18.0-24.4%]; p = 0.023). There were no major adverse cardiac events (MACE) related to the PiCSO intervention.
CONCLUSIONS: PiCSO, as an adjunct to pPCI, was associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population.
结果:这项比较研究是在英国四家医院进行的。在症状发作后12小时内出现前部STEMI的45例患者接受了pPCI加PiCSO(再灌注后开始;n=45),并与来自INFUSE-AMI的倾向评分匹配的对照队列(n=80)进行了比较。梗死面积(占左心室质量的百分比,PiCSO组第5天通过心脏磁共振(CMR)测量的中位数[四分位数范围])显着降低(14.3%[95%CI9.2-19.4%]与21.2%[95%CI18.0-24.4%];p=0.023)。没有与PiCSO干预相关的主要不良心脏事件(MACE)。
结论:PiCSO,在倾向评分匹配的人群中,作为pPCI的辅助治疗,与前STEMI后第5天梗死面积降低相关.