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Abstract：
BACKGROUND: The aim of this clinical research was to investigate the effects of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size at 5 days after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI).
RESULTS: This comparative study was carried out in four UK hospitals. Forty-five patients with anterior STEMI presenting within 12 h of symptom onset received pPCI plus PiCSO (initiated after reperfusion; n = 45) and were compared with a propensity score-matched control cohort from INFUSE-AMI (n = 80). Infarct size (% of LV mass, median [interquartile range]) measured by cardiac magnetic resonance (CMR) at day 5 was significantly lower in the PiCSO group (14.3% [95% CI 9.2-19.4%] vs. 21.2% [95% CI 18.0-24.4%]; p = 0.023). There were no major adverse cardiac events (MACE) related to the PiCSO intervention.
CONCLUSIONS: PiCSO, as an adjunct to pPCI, was associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population.
RESULTS: This comparative study was carried out in four UK hospitals. Forty-five patients with anterior STEMI presenting within 12 h of symptom onset received pPCI plus PiCSO (initiated after reperfusion; n = 45) and were compared with a propensity score-matched control cohort from INFUSE-AMI (n = 80). Infarct size (% of LV mass, median [interquartile range]) measured by cardiac magnetic resonance (CMR) at day 5 was significantly lower in the PiCSO group (14.3% [95% CI 9.2-19.4%] vs. 21.2% [95% CI 18.0-24.4%]; p = 0.023). There were no major adverse cardiac events (MACE) related to the PiCSO intervention.
CONCLUSIONS: PiCSO, as an adjunct to pPCI, was associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population.
摘要：
背景：这项临床研究的目的是研究压力控制间歇性冠状静脉窦闭塞（PiCSO）对ST段抬高型心肌梗死（STEMI）患者经皮冠状动脉介入治疗（pPCI）后第5天梗死面积的影响。
结果：这项比较研究是在英国四家医院进行的。在症状发作后12小时内出现前部STEMI的45例患者接受了pPCI加PiCSO（再灌注后开始；n=45），并与来自INFUSE-AMI的倾向评分匹配的对照队列（n=80）进行了比较。梗死面积（占左心室质量的百分比，PiCSO组第5天通过心脏磁共振（CMR）测量的中位数[四分位数范围]）显着降低（14.3％[95％CI9.2-19.4％]与21.2%[95%CI18.0-24.4%]；p=0.023)。没有与PiCSO干预相关的主要不良心脏事件（MACE）。
结论：PiCSO，在倾向评分匹配的人群中,作为pPCI的辅助治疗,与前STEMI后第5天梗死面积降低相关.
结果：这项比较研究是在英国四家医院进行的。在症状发作后12小时内出现前部STEMI的45例患者接受了pPCI加PiCSO（再灌注后开始；n=45），并与来自INFUSE-AMI的倾向评分匹配的对照队列（n=80）进行了比较。梗死面积（占左心室质量的百分比，PiCSO组第5天通过心脏磁共振（CMR）测量的中位数[四分位数范围]）显着降低（14.3％[95％CI9.2-19.4％]与21.2%[95%CI18.0-24.4%]；p=0.023)。没有与PiCSO干预相关的主要不良心脏事件（MACE）。
结论：PiCSO，在倾向评分匹配的人群中,作为pPCI的辅助治疗,与前STEMI后第5天梗死面积降低相关.
