%0 Journal Article
%T Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study.
%A Egred M
%A Bagnall A
%A Spyridopoulos I
%A Purcell IF
%A Das R
%A Palmer N
%A Grech ED
%A Jain A
%A Stone GW
%A Nijveldt R
%A McAndrew T
%A Zaman A
%J Int J Cardiol Heart Vasc
%V 28
%N 0
%D Jun 2020
%M 32435689
暂无%R 10.1016/j.ijcha.2020.100526
%X <B>BACKGROUND: </B>The aim of this clinical research was to investigate the effects of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size at 5 days after primary percutaneous coronary intervention (pPCI) in patients with ST-segment elevation myocardial infarction (STEMI).<BR><B>RESULTS: </B>This comparative study was carried out in four UK hospitals. Forty-five patients with anterior STEMI presenting within 12 h of symptom onset received pPCI plus PiCSO (initiated after reperfusion; n = 45) and were compared with a propensity score-matched control cohort from INFUSE-AMI (n = 80). Infarct size (% of LV mass, median [interquartile range]) measured by cardiac magnetic resonance (CMR) at day 5 was significantly lower in the PiCSO group (14.3% [95% CI 9.2-19.4%] vs. 21.2% [95% CI 18.0-24.4%]; p = 0.023). There were no major adverse cardiac events (MACE) related to the PiCSO intervention.<BR><B>CONCLUSIONS: </B>PiCSO, as an adjunct to pPCI, was associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population.