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Abstract：
Concentration of PAH in bivalves (Arca senilis) and human health risks due to consumption was examined in samples collected from southern Nigeria and analysed using gas chromatography. Mean PAH concentration (ngkg-1) ranged from 12.0 ± 5.0-5500.0 ± 1000 with a significant difference (p < 0.001) while total PAH ranged from 3000.0-16,000.0. Concentrations (ngkg-1) of PAH4 varied from 250 to 15268.0 while concentrations of PAH8 ranged from 542.0 to 15620.7 with significant difference (p < 0.001). Diagnostic ratios for PAH source distinction suggested mixture of petrogenic and pyrogenic sources. Dietary daily intake-DDI (ng/kg/day) of individual PAHs ranged from 1.04 to 9.86 while DDI for PAH4 and PAH8 were 340.8 and 379.8 respectively. Carcinogenic potencies (ngkg-1) varied from 0.012 to 900.0 for individual PAH while carcinogenic toxic equivalent (TEQs) values were 1916.2, 572.49 and 1914.4 for total PAH, PAH4 and PAH8 respectively. The Excess cancer risk (ECR) for individual PAHs, PAH4 and PAH8 were all <10-6. DDI and ECR values obtained were below USEPA threshold concentration/limits indicating minimal health risk concerns while PAH4 and PAH8 concentrations were also below the EU regulatory limits (30 μg kg-1) for PAH4. The margin of exposures were above the 10,000 critical limit proposed by EFSA while incremental life cancer risk (ILCR) value (10-5 - 10-9) also suggests low potential health risk for consumers of the sea food. The screening value (SV) was 0.095 but lower than observed TEQs values indicating potential health concerns. The study concluded that consumers of bivalves (Arca senilis) in southern Nigeria generally have minimal health risk concern via consumption but regular monitoring is required to detect changes.
摘要：
在从尼日利亚南部收集的样品中检查了双壳类动物（Arcasenilis）中PAH的浓度以及由于食用引起的人类健康风险，并使用气相色谱法进行了分析。平均PAH浓度(ngkg-1)范围为12.0±5.0-5500.0±1000,具有显著差异(p<0.001),而总PAH范围为3000.0-16,000.0。PAH4的浓度（ngkg-1）从250到15268.0变化，而PAH8的浓度从542.0到15620.7变化，差异显着（p<0.001）。PAH来源区分的诊断比率表明了岩源和热源的混合物。个体PAHs的饮食每日摄入量DDI（ng/kg/天）为1.04至9.86，而PAH4和PAH8的DDI分别为340.8和379.8。单个PAH的致癌效力（ngkg-1）在0.012至900.0之间变化，而总PAH的致癌毒性当量（TEQs）值分别为1916.2、572.49和1914.4，分别为PAH4和PAH8。个体PAHs的过度癌症风险(ECR)，PAH4和PAH8均<10-6。获得的DDI和ECR值低于USEPA阈值浓度/限值，表明健康风险最小，而PAH4和PAH8浓度也低于欧盟PAH4的监管限值（30μgkg-1）。暴露幅度高于EFSA提出的10,000个关键限值，而增量生命癌症风险（ILCR）值（10-5-10-9）也表明，海鲜消费者的潜在健康风险较低。筛查值（SV）为0.095，但低于观察到的TEQs值，表明潜在的健康问题。该研究得出的结论是，尼日利亚南部的双壳类（Arcasenilis）消费者通常对消费的健康风险担忧很小，但需要定期监测以检测变化。
