关键词: ALPPS Future liver remnant Hepatic regeneration Liver venous deprivation Portal vein embolization Radiation lobectomy

Mesh : Biliary Tract Neoplasms / therapy Embolization, Therapeutic / adverse effects methods Hepatectomy / adverse effects methods Humans Liver / diagnostic imaging physiopathology Liver Neoplasms / therapy Liver Regeneration / physiology Portal Vein / surgery Preoperative Care

来  源:   DOI:10.1007/s11912-020-00922-x   PDF(Sci-hub)

Abstract:
For three decades, portal vein embolization (PVE) has been the \"gold-standard\" strategy to hypertrophy the anticipated future liver remnant (FLR) in advance of major hepatectomy. During this time, CT volumetry was the most common method to preoperatively assess FLR quality and function and used to determine which patients are appropriate surgical candidates. This review provides the most up-to-date methods for preoperatively assessing the anticipated FLR and summarizes data from the currently available strategies used to induce FLR hypertrophy before surgery for hepatobiliary malignancy.
Functional and physiological imaging is increasingly replacing standard CT volumetry as the method of choice for preoperative FLR assessment. PVE, associating liver partition and portal vein ligation, radiation lobectomy, and liver venous deprivation are all currently available techniques to hypertrophy the FLR. Each strategy has pros and cons based on tumor type, extent of resection, presence or absence of underlying liver disease, age, performance status, complication rates, and other factors. Numerous strategies can lead to FLR hypertrophy and improve the safety of major hepatectomy. Which is best has yet to be determined.
摘要:
三十年来,门静脉栓塞术(PVE)已成为“金标准”策略,可在大肝切除术前肥大预期的未来肝残存(FLR)。在此期间,CT容积法是术前评估FLR质量和功能的最常用方法,用于确定哪些患者是合适的手术候选人。这篇综述提供了术前评估预期FLR的最新方法,并总结了目前用于在肝胆恶性肿瘤手术前诱导FLR肥大的可用策略的数据。
功能和生理成像越来越多地取代标准CT容积法作为术前FLR评估的首选方法。PVE,联合肝分区和门静脉结扎,放射性肺叶切除术,和肝静脉剥夺都是目前可用的肥大FLR的技术。每种策略都有根据肿瘤类型的利弊,切除范围,是否存在潜在的肝脏疾病,年龄,性能状态,并发症发生率,和其他因素。许多策略可以导致FLR肥大并提高肝切除术的安全性。哪个最好还没有确定。
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