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Abstract：
To understand the neural basis of behavior, it is important to reveal how movements are planned, executed, and refined by networks of neurons distributed throughout the nervous system. Here, we report the neuroanatomical organization and behavioral roles of cerebellospinal (CeS) neurons. Using intersectional genetic techniques, we find that CeS neurons constitute a small minority of excitatory neurons in the fastigial and interpositus deep cerebellar nuclei, target pre-motor circuits in the ventral spinal cord and the brain, and control distinct aspects of movement. CeS neurons that project to the ipsilateral cervical cord are required for skilled forelimb performance, while CeS neurons that project to the contralateral cervical cord are involved in skilled locomotor learning. Together, this work establishes CeS neurons as a critical component of the neural circuitry for skilled movements and provides insights into the organizational logic of motor networks.
摘要：
为了理解行为的神经基础，重要的是要揭示运动是如何计划的，执行,并由分布在整个神经系统中的神经元网络完善。这里,我们报道了小脑脊髓（CeS）神经元的神经解剖组织和行为作用。使用交叉遗传技术，我们发现CeS神经元构成小脑小脑顶核和中间深层核的一小部分兴奋性神经元，瞄准腹侧脊髓和大脑的运动前回路，并控制运动的不同方面。投射到同侧颈索的CeS神经元需要熟练的前肢表现，而投射到对侧颈索的CeS神经元参与熟练的运动学习。一起,这项工作将CeS神经元确立为熟练运动的神经电路的关键组成部分，并提供了对运动网络组织逻辑的见解。
