{Reference Type}: Journal Article
{Title}: Cerebellospinal Neurons Regulate Motor Performance and Motor Learning.
{Author}: Sathyamurthy A;Barik A;Dobrott CI;Matson KJE;Stoica S;Pursley R;Chesler AT;Levine AJ;
{Journal}: Cell Rep
{Volume}: 31
{Issue}: 6
{Year}: 05 2020 12
暂无{DOI}: 10.1016/j.celrep.2020.107595
{Abstract}: To understand the neural basis of behavior, it is important to reveal how movements are planned, executed, and refined by networks of neurons distributed throughout the nervous system. Here, we report the neuroanatomical organization and behavioral roles of cerebellospinal (CeS) neurons. Using intersectional genetic techniques, we find that CeS neurons constitute a small minority of excitatory neurons in the fastigial and interpositus deep cerebellar nuclei, target pre-motor circuits in the ventral spinal cord and the brain, and control distinct aspects of movement. CeS neurons that project to the ipsilateral cervical cord are required for skilled forelimb performance, while CeS neurons that project to the contralateral cervical cord are involved in skilled locomotor learning. Together, this work establishes CeS neurons as a critical component of the neural circuitry for skilled movements and provides insights into the organizational logic of motor networks.