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Abstract：
Oligonucleotide/oligosaccharide-binding (OB)-fold proteins play essential roles in the regulation of genome and its correct transformation to the subsequent generation. To maintain the genomic stability, OB-fold proteins are implicated in various cellular processes including DNA replication, DNA repair, cell cycle regulation and maintenance of telomere. The diverse functional spectrums of OB-fold proteins are mainly due to their involvement in protein-DNA and protein-protein complexes. Mutations and consequential structural alteration in the OB-fold proteins often lead to severe diseases. Here, we have investigated the structure, function and mode of action of OB-fold proteins (RPA, BRCA2, DNA ligases and SSBs1/2) in cellular pathways and their relationship with diseases and their possible use in therapeutic intervention. Due to the crucial role of OB-fold proteins in regulating the key physiological process, a detailed structural understanding in the context of underlying mechanism of action and cellular complexity offers a new avenue to target OB-proteins for therapeutic intervention.
摘要：
寡核苷酸/寡糖结合（OB）-折叠蛋白在基因组的调节及其对后代的正确转化中起着至关重要的作用。为了保持基因组的稳定性,OB-折叠蛋白涉及各种细胞过程，包括DNA复制，DNA修复,端粒的细胞周期调控与维持。OB折叠蛋白的不同功能谱主要是由于它们参与蛋白质-DNA和蛋白质-蛋白质复合物。OB折叠蛋白中的突变和相应的结构改变通常导致严重的疾病。这里,我们已经调查了结构，OB折叠蛋白的功能和作用方式(RPA，BRCA2，DNA连接酶和SSBs1/2）在细胞通路中的作用及其与疾病的关系及其在治疗干预中的可能用途。由于OB-fold蛋白在调节关键生理过程中的关键作用，在潜在作用机制和细胞复杂性的背景下,详细的结构理解为靶向OB蛋白进行治疗干预提供了新的途径.
