{Reference Type}: Journal Article
{Title}: Structure, function and therapeutic implications of OB-fold proteins: A lesson from past to present.
{Author}: Amir M;Mohammad T;Dohare R;Islam A;Ahmad F;Imtaiyaz Hassan M;
{Journal}: Brief Funct Genomics
{Volume}: 19
{Issue}: 5
{Year}: 12 2020 4
{Factor}: 4.84
{DOI}: 10.1093/bfgp/elaa008
{Abstract}: Oligonucleotide/oligosaccharide-binding (OB)-fold proteins play essential roles in the regulation of genome and its correct transformation to the subsequent generation. To maintain the genomic stability, OB-fold proteins are implicated in various cellular processes including DNA replication, DNA repair, cell cycle regulation and maintenance of telomere. The diverse functional spectrums of OB-fold proteins are mainly due to their involvement in protein-DNA and protein-protein complexes. Mutations and consequential structural alteration in the OB-fold proteins often lead to severe diseases. Here, we have investigated the structure, function and mode of action of OB-fold proteins (RPA, BRCA2, DNA ligases and SSBs1/2) in cellular pathways and their relationship with diseases and their possible use in therapeutic intervention. Due to the crucial role of OB-fold proteins in regulating the key physiological process, a detailed structural understanding in the context of underlying mechanism of action and cellular complexity offers a new avenue to target OB-proteins for therapeutic intervention.