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Abstract：
IgG4-related disease (IgG4-RD) is an inflammatory and fibrosing disease which causes tumor-like swelling of organs and commonly mimics symptoms of malignancy. It has been increasing in prevalence in the last decade, but esophageal involvement remains rare. IgG4-RD was first known to involve certain organs, such as the pancreas. It has, since, been described as a systemic disease process. IgG4-RD should be considered in patients presenting with dysphagia. Initiation of appropriate treatment with corticosteroids can avoid unnecessary procedures and improve outcomes. The aim of this review is to discuss 17 cases of IgG4-RD of the esophagus. Literature review was conducted using NCBI database (PMC and PubMed filters) using the keywords \"IgG4 disease,\" \"sclerosing,\" \"esophagus\" and \"gastrointestinal.\" The search was narrowed to include cases describing IgG4 disease of the esophagus using the same filters. Literature review identified 16 documented cases of IgG4-RD involving the esophagus. Upon literature review, it remains clear that it is extremely rare for IgG4-RD to affect the esophagus. Sixteen cases have been reported. We present a 17th case and discuss the implications of IgG4-RD. It is important to keep a broad differential diagnosis that includes IgG4-RD for patients presenting with dysphagia, especially when symptoms are refractory.
摘要：
IgG4相关疾病(IgG4-RD)是一种炎性和纤维化疾病,其引起器官的肿瘤样肿胀并且通常模拟恶性肿瘤的症状。在过去的十年中，它的患病率一直在增加，但食管受累仍然很少见.IgG4-RD最初被认为涉及某些器官，比如胰腺。它有,因为,被描述为全身性疾病过程。出现吞咽困难的患者应考虑IgG4-RD。开始使用皮质类固醇进行适当的治疗可以避免不必要的手术并改善预后。本文对17例食管IgG4-RD进行综述。使用NCBI数据库（PMC和PubMed过滤器）使用关键字\“IgG4疾病，“\”硬化，\"\"食道\"和\"胃肠。“搜索范围缩小到包括使用相同过滤器描述食道IgG4疾病的病例。文献综述确定了16例记录的涉及食管的IgG4-RD病例。在文献综述中，很明显,IgG4-RD影响食道的情况极为罕见.已报告16例。我们介绍了第17例病例，并讨论了IgG4-RD的含义。对于出现吞咽困难的患者，应进行广泛的鉴别诊断，包括IgG4-RD，尤其是当症状难治时。
