背景:食管疾病和慢性肝病在世界范围内很常见,并且显著影响生活质量。这些条件之间错综复杂的联系,包括像GERD这样的食管疾病,Barrett食管和食道癌影响慢性肝病,仍然知之甚少。
目的:综述食管疾病与慢性肝病的关系,评估流行病学,病理生理学和治疗因素。
方法:我们回顾了关于食管疾病与慢性肝病之间关系的文献,包括肝硬化,使用PubMed数据库结果:食管疾病,如胃食管反流病,巴雷特的食道,食道癌,食管运动障碍和食管念珠菌病在肝硬化患者中普遍存在,加重肝脏疾病的负担。这些疾病具有多方面的症状学和致病基础,对肝硬化患者构成重大挑战,需要仔细诊断和管理。此外,经常用于这些疾病的疗法,如质子泵抑制剂,由于潜在的不良反应和药代动力学改变,肝硬化患者需要仔细考虑。由于可能与药物的相互作用和不良反应的风险,在肝硬化患者中管理食管疾病需要谨慎的方法。此外,与这些情况相关的症状通常会因肝硬化患者的常见干预措施而加剧,如食管静脉曲张的绑扎。
结论:食管疾病常见于肝硬化并增加疾病负担。由于复杂的症状和治疗风险,这些疾病需要小心管理。质子泵抑制剂和其他疗法必须谨慎使用,因为肝硬化干预会使症状恶化。
BACKGROUND: Oesophageal disorders and chronic liver disease are common worldwide and significantly impact quality of life. The intricate link between these conditions, including how oesophageal disorders like GERD, Barrett\'s oesophagus and oesophageal cancer affect and are affected by chronic liver disease, remains poorly understood.
OBJECTIVE: To review the relationship between oesophageal disorders and chronic liver disease, evaluating epidemiology, pathophysiology and therapeutic factors.
METHODS: We reviewed the literature on the relationship between oesophageal disorders and chronic liver disease, including cirrhosis, using the PubMed database RESULTS: Oesophageal disorders such as gastroesophageal reflux disease, Barrett\'s oesophagus, oesophageal cancer, oesophageal motor disorders and oesophageal candidiasis are prevalent among individuals with cirrhosis, exacerbating the burden of liver disease. These diseases have a multifaceted symptomatology and pathogenic basis, posing a significant challenge in cirrhotic patients that necessitates careful diagnosis and management. Additionally, therapies frequently used for these diseases, such as proton pump inhibitors, require careful consideration in cirrhotic patients due to potential adverse effects and altered pharmacokinetics. Managing oesophageal disorders in cirrhotic patients requires a cautious approach due to possible interactions with medications and the risk of adverse effects. Furthermore, symptoms associated with these conditions are often exacerbated by common interventions in patients with cirrhosis, such as band ligation for oesophageal varices.
CONCLUSIONS: Oesophageal disorders are common in cirrhosis and increase the disease burden. These conditions require careful management due to complex symptoms and treatment risks. Proton pump inhibitors and other therapies must be used cautiously, as cirrhosis interventions can worsen symptoms.