关键词： ATXN1L Breast cancer CELSR1 COPD Capicua Cdc42 DNA methylation profiling DNA mismatch repair ECM Ewing's tumour HDAC Lynch syndrome Mendelian randomisation PD-L1 Rac1 RhoA RhoGTPase SWI/SNF TILs TREM2 Toll-like receptors X chromosome inactivation acute response ageing algorithm anti-sense lncRNA apoptosis artificial intelligence astrocytoma atherosclerosis autophagy biologics biomarker risk-management cancer predisposition chemotaxis chronic inactive lesions chronic kidney disease clear cell renal cell carcinoma clinical trial clonogen collective cell migration colorectal cancer computational pathology decision support demyelinated lesions development diabetes diagnosis digital histology durotaxis endometrial cancer ependymoma exosomes foam cells gene variant interpretation genome-wide association study glioblastoma glomerulonephritis grey matter host-directed therapy hypoxia hypoxia-inducible factor image analysis immunity immunoediting immunotherapy inflammation inflammatory lesions interleukin-6 invasion ionising radiation late response long intergenic non-coding RNA long non-coding RNA macrophage macropinocytosis mass cytometry medulloblastoma mesenchymal stem cells mesenchymal stromal cells metabolic disorders metastasis miRNA migration monocyte multiple sclerosis neoplasia nephropathology neuroblastoma neurodegenerative disease neurogenesis oxidative stress oxygen personalised treatment precision imaging pseudohypoxia receptor scATACseq senescence sex differences single-cell RNAseq small airways stem cell stem cells tissue regeneration translation transplantation tuberculosis tumour microenvironment white matter

Mesh ： Animals Biomarkers, Tumor Epigenesis, Genetic Humans Inflammation / pathology Neoplasms / genetics pathology Tumor Microenvironment / genetics immunology United Kingdom

来  源：   DOI：10.1002/path.5425   PDF(Sci-hub)

Abstract：
This year\'s Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
摘要：
今年的“病理学杂志”的年度评论期包含18个关于病理学当前研究领域的特邀评论。主题领域反映了该杂志涵盖的广泛主题，今年包括数字组织病理学软件的开发和应用，在病理学实践中实施生物标志物；遗传学和表观遗传学，和疾病中的基质影响。评论由各自领域的专家撰写，并提供所选领域的全面更新，我们对疾病的认识最近取得了相当大的进展。©2020英国和爱尔兰病理学会。由JohnWiley&Sons出版,Ltd.
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