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Abstract：
The antimicrobial properties of two-dimensional materials such as graphene-based surfaces are vital for environmental and biomedical applications. Here, the improvement of the antibacterial property of reduced graphene oxide by the preparation of rGO-CuO nanocomposite films was reported. The rGO-CuO nanocomposites were synthesized via a simple hydrothermal method, and the nanocomposite films were fabricated by filtering through a polytetrafluoroethylene (PTFE) filter with the assistance of a vacuum filtration unit. After characterization of the nanocomposite films, the antibacterial properties were tested against Pseudomonas aeruginosa PAO1. The fabricated rGO-CuO nanocomposite films exhibited excellent antibacterial activity, leading to complete bacterial inactivation upon contact. The antibacterial properties were closely linked to the reactive oxygen species (ROS) independent pathway rather than the ROS-dependent pathway. This work provides an insight into the antibacterial mechanisms of reduced GO and copper oxide composite film for water treatment systems and the potential application of these nanocomposites in biomedicine.
摘要：
二维材料如基于石墨烯的表面的抗微生物特性对于环境和生物医学应用至关重要。这里,报道了通过制备rGO-CuO纳米复合薄膜来改善还原氧化石墨烯的抗菌性能。通过简单的水热法合成了rGO-CuO纳米复合材料，并且通过在真空过滤单元的辅助下通过聚四氟乙烯(PTFE)过滤器过滤来制备纳米复合材料膜。经过表征的纳米复合薄膜，对铜绿假单胞菌PAO1的抗菌性能进行了测试。制备的rGO-CuO纳米复合膜具有优异的抗菌活性,导致接触时细菌完全失活。抗菌特性与活性氧（ROS）独立途径而不是ROS依赖性途径密切相关。这项工作提供了对用于水处理系统的还原GO和氧化铜复合膜的抗菌机理以及这些纳米复合材料在生物医学中的潜在应用的见解。
